基于中西医临床病证特点的腰椎间盘突出症动物模型分析  

Animal Model Analysis of Lumbar Disc Herniation Based on Clinical Features of Traditional Chinese and Western Medicine

作　　者：李法杰 谷金玉 张悦 夏迪 万田豪 杨满红 张清[1] LI Fajie;GU Jinyu;ZHANG Yue;XIA Di;WAN Tianhao;YANG Manhong;ZHANG Qing(Wang Jing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院望京医院,北京100102 [2]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《世界中医药》2024年第23期3696-3701,共6页World Chinese Medicine

基　　金：中央级公益性科研院所基本科研业务费课题“优势病种-医院制剂-新药研发”专项(ZZ15-XY-PT-12);北京市自然科学基金项目(7254529)。

摘　　要：目的:基于腰椎间盘突出症(LDH)的中西医临床病证特点,构建临床吻合度较高的LDH动物模型及评价指标。方法:根据中西医临床LDH各项诊断指标,分别评价LDH动物模型与LDH中西医诊断标准的吻合度,每符合LDH西医前5项诊断标准中的1项赋值为25%,超过3项(包含3项)赋值为75%,符合第6项标准赋值为25%,每符合中医临床主证中的1项赋值为20%,次证每符合1项为8%,并根据赋值情况对现有LDH动物模型的优缺点及临床吻合度进行分析,初步提出LDH中西医病证结合动物模型评价指标。结果:现有LDH动物模型与临床吻合度较高的模型主要包括自体及异体髓核移植损伤神经根模型、针刺直接损伤纤维环模型;其余LDH动物模型分属于一般吻合度及低吻合度模型。结论:目前LDH动物模型无法有效模拟LDH的整体疾病过程和状态,缺少对中医证候的正确反映。故构建临床吻合度较高的LDH病证结合动物模型及其评价指标需进一步挖掘和改进。Objective Based on the clinical features of lumbar disc herniation(LDH)in traditional Chinese and western medicine,the LDH animal model and evaluation index with high clinical anastomosis were constructed.Methods According to the diagnostic indexes of LDH in traditional Chinese medicine(TCM)and Western medicine clinical practices,evaluation was conducted respectively on the clinical anastomosis of the LDH animal model and the LDH diagnostic criteria of traditional Chinese and Western medicine.For each of the first five diagnostic criteria of LDH in Western medicine,a score of 25%was assigned for each criterion met.If three or more(including three)of these criteria were met,a score of 75%was assigned.If the sixth criterion was met,a score of 25%was assigned.For TCM clinical syndromes,a score of 20%was assigned for each principal syndrome met,and a score of 8%for each secondary syndrome met.Based on the assignment,the advantages and disadvantages of the existing LDH animal model and the clinical anastomosis were analyzed.Afterward,the evaluation index of the LDH animal model combining TCM and Western medicine disease and syndrome was preliminarily proposed.Results The LDH animal models with high clinical anastomosis mainly include the nerve root injury model of autologous and allogeneic nucleus pulposus transplantation and the anulus fibrosus injury model of direct acupuncture.The other LDH animal models are categorized into models with general and low clinical anastomosis.Conclusion The existing LDH animal models cannot effectively simulate the whole disease process and state of LDH,and lack the correct reflection of TCM syndrome.Therefore,it is necessary to further explore and improve the construction of LDH disease-syndrome combined animal models with high clinical anastomosis and their evaluation indexes.

关 键 词：腰椎间盘突出症 中西医临床病证特点 动物模型 吻合度 评价指标 

分 类 号：R274.9[医药卫生—中西医结合]