痛风“湿-热-寒-瘀-虚”复杂病机网络及生物学基础研究进展  

Complex Pathogenesis Network of“Dampness-heat-cold-stasis-deficiency”in Gout and Its Biological Basis:A Review

作　　者：彭紫凝 邓茜 孟凡雨 晏蔚田 刘念 彭江云 PENG Zining;DENG Qian;MENG Fanyu;YAN Weitian;LIU Nian;PENG Jiangyun(First School of Clinical Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China;The First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南中医药大学第一临床医学院,昆明650500 [2]云南中医药大学第一附属医院,昆明650021

出　　处：《世界中医药》2024年第23期3725-3730,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(81960863);国家中医药管理局高水平中医药重点学科(风湿痹病学)建设项目(zyyzdxk-2023189);云南省教育厅科学研究基金项目(2024Y380)。

摘　　要：目前痛风患病率逐年上升,但是发病机制复杂,临床上缺乏切实有效的治疗药物。中医药治疗痛风疗效确切,其病机可归为“湿-热-寒-瘀-虚”网络。从中医学阐述“湿-热-寒-瘀-虚”复杂病机网络的内涵,结合现代医学肠道菌群紊乱、炎症反应、氧化应激、微循环障碍和免疫功能降低的生物学基础,为痛风中医辨证施治及防治提供参考,也为中医药的发展完善其现代内涵。The prevalence of gout has been rising year by year,but its pathogenesis is complex,and there is a lack of effective therapeutic drugs in clinical practice.Traditional Chinese medicine(TCM)has been proven to be effective in treating gout,with its pathogenesis categorized under the“dampness-heat-cold-stasis-deficiency”network.This article elaborates on the connotation of the complex pathogenesis network of“dampness-heat-cold-stasis-deficiency”from the perspective of TCM,and combines the biological basis of modern medicine,including intestinal flora imbalance,inflammatory response,oxidative stress,microcirculation disorders,and immune dysfunction,to provide a reference for TCM syndrome differentiation,treatment,and prevention of gout.This also contributes to the development of TCM and the refinement of its modern connotations.

关 键 词：痛风 湿-热-寒-瘀-虚 复杂病机网络 肠道菌群紊乱 炎症反应 氧化应激 微循环障碍 免疫功能降低 

分 类 号：R255.6[医药卫生—中医内科学]