刀豆蛋白A生物活性及应用的研究进展  

Research Progress on Biological Activity and Application of Concanavalin A

作　　者：杨磊[1,2] 罗婧菱 李浩辰 YANG Lei;LUO Jingling;LI Haochen(First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530000,China;Key Laboratory of Chinese Medicine Clinical Research,Education Department of Guangxi Zhuang Autonomous Region,Nanning 530000,China;Tianjin International Travel Health Care Center(Tianjin Customs Port Outpatient Department),Tianjin 300000,China)

机构地区：[1]广西中医药大学第一附属医院,南宁530000 [2]广西高校中医临床研究重点实验室,南宁530000 [3]天津国际旅行卫生保健中心(天津海关口岸门诊部),天津300000

出　　处：《食品与发酵科技》2025年第1期125-131,共7页Food and Fermentation Science & Technology

基　　金：广西壮族自治区卫健委自筹项目(Z20210130、Z20210817);广西中医药大学第一附属医院青年拔尖人才项目。

摘　　要：随着刀豆蛋白A(Concanavalin A,ConA)的纯化技术和结构性质的深入研究,其应用领域不断扩大。ConA在制备各类肝损伤实验动物模型方面应用较多,对肝脏疾病的诊断与治疗起到了关键作用。在癌症研究中,ConA展现了抗肿瘤能力,能够通过促进细胞凋亡、抑制细胞增殖及阻断血管生成等多种机制,抑制肿瘤细胞的生长和扩散。由于其在临床上的抗癌效果令人瞩目,因此包含ConA的抗癌药物已被广泛用于治疗。此外,ConA在增强人体免疫力方面也显示出了重要的作用,特别是在激活T淋巴细胞方面。它不仅在生物学和生物化学研究中被广泛应用,还在糖蛋白分子的鉴定、临床诊断以及化学和医学研究等领域发挥着重要作用。该文旨在全面回顾ConA目前的研究进展,并对其未来发展方向进行展望。With the in-depth study of concanavalin A(short for ConA)purification methods and its structural properties,its application scope has been continuously expanding.ConA is used to create various experimental animal models of liver injury,which plays a crucial role in the diagnosis and treatment of liver diseases.In the field of cancer research,ConA has shown anti-tumor ability through multiple mechanisms like inducing cell apoptosis,inhibiting cell proliferation,and suppressing angiogenesis,effectively restraining the growth and metastasis of cancer cells.Its clinical anti-cancer effects are remarkable,and anti-cancer drugs with ConA have been widely used in clinical treatment.In addition,ConA plays an important role in enhancing human immunity especially in activating the T lymphocytes.ConA is widely used in the fields of biology and biochemistry research.Additionally,ConA has been applied in glycoprotein molecule identification,clinical diagnosis,chemistry,medicine,and other research areas.This article provides a comprehensive review of the current research progress on ConA and outlines its future development directions.

关 键 词：刀豆蛋白A 肿瘤 临床诊断 免疫 

分 类 号：Q946.1[生物学—植物学]