安徽省2017-2023年出生队列儿童13价肺炎球菌多糖结合疫苗接种现况及空间聚集性分析  

Coverage and spatial clustering analysis of 13-valent pneumococcal conjugate vaccine among the 2017-2023 birth cohorts in Anhui Province

作　　者：毛雷婧 任明雪 林玲 董燕 谢逸石 罗献伟[1] 王斌冰[1] Mao Leijing;Ren Mingxue;Lin Ling;Dong Yan;Xie Yishi;Luo Xianwei;Wang Binbing(Dept of Expanded Program on Immunization,Anhui Provincial Center for Disease Control and Prevention,Hefei 230601)

机构地区：[1]安徽省疾病预防控制中心免疫预防科,合肥230601

出　　处：《安徽医科大学学报》2025年第2期332-338,共7页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生健康委科研项目(编号:AHWJ2021b021)。

摘　　要：目的分析安徽省2017—2023年出生儿童13价肺炎球菌多糖结合疫苗(PCV13)接种现况和空间聚集性。方法通过安徽省免疫规划信息管理系统收集所有2017—2023年出生儿童的PCV13接种信息,分析接种率及特征,并对覆盖率进行空间自相关分析。结果安徽省2017—2023年出生队列儿童PCV13累计覆盖率、累计基础免疫率和累计全程免疫率分别为17.19%、12.12%、9.09%。覆盖率从2017年出生队列的1.14%上升到2022年出生队列的41.59%。首剂接种年龄<3月龄、3~6月龄、7~11月龄、12~23月龄和≥24月龄的比例分别为45.35%、29.84%、5.52%、10.75%和8.53%,不同年度出生队列和不同品种疫苗首剂接种年龄差异有统计学意义(P<0.001)。安徽省不同地区的儿童比较,PCV13累计覆盖率、累计基础免疫率、累计全程免疫率和首剂接种年龄差异均有统计学意义(P<0.001)。2018—2023年出生队列PCV13覆盖率呈明显的空间正相关。局部空间自相关分析显示,“高-高”聚集区集中在安徽中部地区。结论安徽省PCV13接种率较低,地区间差异较大。Objective To evaluate the coverage and spatial clustering of 13-valent pneumococcal conjugate vaccine(PCV13)among the 2017—2023 birth cohorts in Anhui Province.Methods Obtained vaccination data of PCV13 for children born in 2017—2023 from the Anhui Immunization Information Management System.We estimated coverage levels and described characteristics of coverage.The spatial autocorrelation analysis of coverage was conducted.Results Cumulative coverage,cumulative primary immunization coverage and cumulative full-series coverage of PCV13 were 17.19%,12.12%and 9.09%among the 2017—2023 birth cohort in Anhui Province.The coverage of PCV13 increased from 1.14%in the 2017 birth cohort to 41.59%in the 2022 birth cohort.The first dose of PCV13 at ages under 3,3—6,7—11,12—23 and not less than 24 months were 45.35%,29.84%,5.52%,10.75%and 8.53%,respectively.There were significant differences in the ages of the first dose between children of different years of born and kinds of PCV13(P<0.001).Significant differences were also observed in the cumulative coverage,cumulative primary immunization coverage,cumulative full-series coverage of PCV13 and ages of the first dose among children from various residence regions(P<0.001).From 2018 to 2023 birth cohort,the coverage of PCV13 in Anhui Province showed obvious positive spatial autocorrelation.Local spatial autocorrelation analysis showed that the"high-high"agglomeration areas were concentrated in the central area of Anhui.Conclusion The coverage of PCV13 was low in Anhui Province with significant regional differences.

关 键 词：13价肺炎球菌多糖结合疫苗 预防接种 接种率 儿童 出生队列 空间分析 

分 类 号：R186[医药卫生—流行病学] R378.12[医药卫生—公共卫生与预防医学]