产前应激通过破坏子代肠道菌群导致疾病的研究进展  

Recent research progress of prenatal stress-induced disease by disrupting offspring intestinal microbiota

作　　者：何鎣芝 曾词正 陈雪梅 谢谕威 敖当 刘玲(综述) 李文(审校) He Yingzhi;Zeng Cizheng;Chen Xuemei;Xie Yuwei;Ao Dang;Liu Ling;Li Wen(Dept of Pediatrics,The Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001)

机构地区：[1]广东医科大学附属医院儿科,湛江524001

出　　处：《安徽医科大学学报》2025年第2期372-377,共6页Acta Universitatis Medicinalis Anhui

基　　金：广东医科大学附属医院高层次人才科研启动项目(编号:GCC2021009)。

摘　　要：产前应激(PS)是母体妊娠时一种常见的全身性、非特异性应激反应。肠道菌群被称为人体的第二基因组,与人体各大系统相互作用。肠道菌群的改变会影响婴幼儿的发育和健康。随着研究技术的发展,逐渐揭示PS与子代肠道菌群失衡及多个系统疾病的关系。然而,PS破坏子代肠道微生物群的确切机制尚未完全清楚。该文通过对PS破坏子代肠道菌群导致疾病的现有研究进行总结,寻找未来的研究方向,以拓展对婴幼儿疾病发病机制的认知。Prenatal stress is a common,systemic,nonspecific stress response that occurs during pregnancy.The gut microbiota,which is known as the“second genome”of the human body,interacts with all major systems of the body.Changes in the gut microbiota can impact the development and health of infants and young children.Advances in research technology have allowed us to uncover the relationship between prenatal stress and imbalances in offspring intestinal microbiota,as well as the development of multiple systemic diseases.However,the exact mechanisms through which prenatal stress disrupts the gut microbiota of offspring remain incompletely understood.This review summarizes the existing research on diseases caused by prenatal stress disrupting the offspring intestinal flora,and seeks future research directions to expand the understanding of the pathogenesis of infant diseases.

关 键 词：产前应激 母体 肠道菌群 失调 子代 疾病 

分 类 号：R725[医药卫生—儿科]