基于数据挖掘的中药治疗食管癌用药规律分析  

Medication Rule of Traditional Chinese Medicine in Treatment of Esophageal Cancer Based on Data Mining

作　　者：王涵 郭林慧 王旭[1,2] 杨松波 毛宇湘[1] WANG Han;GUO Linhui;WANG Xu;YANG Songbo;MAO Yuxiang(The First Affiliated Hospital of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050011,China;Graduate School of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050091,China;Shijiazhuang Traditional Chinese Medicine Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北中医学院第一附属医院,石家庄050011 [2]河北中医学院研究生院,石家庄050091 [3]石家庄市中医院,石家庄050051

出　　处：《世界中医药》2024年第22期3493-3498,共6页World Chinese Medicine

基　　金：国家中医药管理局第三届国医大师传承工作室建设项目(国中医药办人教函﹝2018﹞119号);河北省中医药管理局科研计划项目(2019012)。

摘　　要：目的:探讨中医药治疗食管癌的用药规律。方法:以食管癌为主题词,收集、整理2010年1月1日至2020年6月1日国家知识基础设施数据库中收载治疗食管癌的方剂,建立食管癌方剂文献研究数据库,采用数据挖掘技术对其用药规律进行分析。结果:纳入符合标准的207篇期刊文献中,共涉及260首方剂和269味中药,中药频次共计2971次。其中中药频次≥15的共有59种,累计出现2133次,治疗食管癌的核心药物有半夏、黄芪、茯苓、白术、当归等,中药功效以补虚药、清热药、化痰止咳平喘药、活血化瘀药、理气药、利水渗湿药为主。药性以温性为主,占41.92%,药味以甘、苦、辛为主,占88.34%,归经与脾胃最为密切,占总频次的37.76%。通过关联规则分析可以得到6种关联强度较高的药对组合,通过聚类分析可提取4大类。结论:治疗食管癌方剂中用药多以补虚、化痰、活血、解毒为主。Objective:To explore the medication rules of traditional Chinese medicine in treating esophageal cancer.Methods:With esophageal cancer as the keyword,this paper collected and organized the prescriptions in the China National Knowledge Infrastructure(CNKI)database from January 1,2010 to June 1,2020 for the treatment of esophageal cancer,established a literature research database of esophageal cancer prescriptions,and used data mining technology to analyze their medication rules.Results:In the included 207 journal documents that meet the standard,a total of 260 prescriptions and 269 traditional Chinese medicines are involved.The frequency of traditional Chinese medicines is 2971 times.Among them,there are 59 kinds of traditional Chinese medicines with a frequency of≥15,with 2133 records.The core medicines for treating esophageal cancer are Rhizoma Pinelliae,Radix Astragali,Poria,Rhizoma Atractylodis Macrocephalae,Radix Angelicae Sinensis,etc.,and the main functions of traditional Chinese medicine are tonifying deficiency,clearing heat,resolving phlegm,relieving cough and asthma,promoting blood circulation and removing blood stasis,regulating Qi,promoting diuresis,and clearing damp.The medicinal properties are mainly warm,which accounts for 41.92%,and the medicinal flavors are mainly sweet,bitter,and spicy,accounting for 88.34%.Channel tropism mainly involves the spleen and stomach,accounting for 37.76%of the total frequency.Through the analysis of association rules,a total of six drug pairs with high association are obtained,and four categories can be extracted through cluster analysis.Conclusion:Most of the medicines used in the prescriptions for the treatment of esophageal cancer focus on tonifying deficiency,resolving phlegm,promoting blood circulation,and detoxification.

关 键 词：食管癌 噎膈 中药 关联规则 聚类分析 数据挖掘 用药规律 文献研究 

分 类 号：R273[医药卫生—中西医结合]