消胀贴外用治疗功能性消化不良脾虚气滞证患者的临床应用  

Clinical Application of Xiaozhang Plaster in Treatment of Patients with Functional Dyspepsia of Spleen Deficiency and Qi Stagnation

作　　者：白桦 李梦然 吴雪梅[3] 李树斌[3] BAI Hua;LI Mengran;WU Xuemei;LI Shubin(Department of General Medicine,BDA Branch of Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100176,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;South Area of Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 102618,China)

机构地区：[1]北京中医药大学东方医院经开院区综合内科,北京100176 [2]北京中医药大学中医学院,北京100029 [3]中国中医科学院广安门医院南区,北京102618

出　　处：《世界中医药》2024年第22期3513-3517,3522,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(81873160)——基于非靶向代谢组学探讨免疫介导性肠病湿热证实质及华重楼活性成分作用机制;北京市科协金桥工程种子资金项目(ZZ19053)——“消胀贴外用治疗脾虚气滞型功能性消化不良的临床应用研究”。

摘　　要：目的:探讨消胀贴外用治疗功能性消化不良(FD)脾虚气滞证患者的临床应用。方法:选取2019年7月至2021年7月中国中医科学院广安门医院南区诊治的FD患者124例作为研究对象,按照随机数字表法随机分为观察组(n=61)和对照组(n=63),观察组采用消胀贴外用治疗,对照组莫沙必利口服治疗,治疗4周,随访1个月。比较2组患者治疗前、治疗后中医症状积分、胃肠激素水平、胃排空率、焦虑抑郁量表(HADS)积分、健康调查量表36(SF-36)积分和临床疗效。结果:与对照组比较,治疗后观察组的胃脘痞闷或胀痛、纳呆、面色萎黄、便溏、中医症状总积分、胃泌素、胃排空率,以及HADS积分、SF-36积分更优(P<0.05),观察组临床总有效率高于对照组(P<0.05)。结论:消胀贴外用治疗FD脾虚气滞证患者,能增强患者胃肠动力,减轻患者临床症状,改善患者焦虑抑郁情况及生命质量。从近期随访看,观察组疗效可能较对照组更持久。Objective:To observe the clinical application of Xiaozhang Plaster in the treatment of patients with functional dyspepsia(FD)of spleen deficiency and Qi stagnation.Methods:A total of 124 FD patients admitted to the south area of Guangf Guan Hospital,China Academy of Chinese Medical Sciences from July 2019 to July 2021 were selected as research subjects.They were randomly divided into an observation group(n=61)and a control group(n=63).The observation group was treated with Xiaozhang Plaster,and the control group was treated with mosapride orally for four weeks.They were followed up for one month after treatment.Traditional Chinese medicine(TCM)symptom score,gastrointestinal hormone level,gastric emptying rate,hospital anxiety and depression scale(HADS)points,medical outcomes study 36-item short from health survey(SF-36)points,and clinical efficacy of the two groups were compared before and after treatment.Results:Compared with those in that control group,the patients in the observation group had more obvious improvement in terms of gloms and oppression in the stomach duct or distending pain and distention,anorexia,sallow complexion,and loose stool,as well as total symptom score,gastrin,gastric emptying rate,HADS points,and SF-36 points(P<0.05).The total clinical effective rate in the observation group was higher than that in the control group(P<0.05).Conclusion:Xiaozhang Plaster can enhance gastrointestinal motility,reduce clinical symptoms,and improve anxiety,depression,and quality of life of patients with FD of spleen deficiency and Qi stagnation.According to the recent follow-up,the efficacy of the observation group may be more durable than the control group.

关 键 词：消胀贴 功能性消化不良 脾虚气滞 临床疗效 

分 类 号：R242[医药卫生—中医临床基础] R259[医药卫生—中医学]