基于线粒体-内质网偶联结构探讨从肾论治阿尔茨海默病的科学内涵  

Scientific Connotation of Treating Alzheimer′s Disease from Kidney Based on Mitochondria-endoplasmic Reticulum Structure Coupling

作　　者：王孟菲 高卫平[3] 袁永[1,2] 贾亚泉 张振强[1,2] 杜若飞 宋军营[1,2] WANG Mengfei;GAO Weiping;YUAN Yong;JIA Yaquan;ZHANG Zhenqiang;DU Ruofei;SONG Junying(Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan Province,Zhengzhou 450046,China;Traditional Chinese Medicine School,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学中医药科学院,郑州450046 [2]豫药全产业链研发河南省协同创新中心,郑州450046 [3]河南中医药大学中医学院,郑州450046

出　　处：《世界中医药》2024年第24期3855-3859,共5页World Chinese Medicine

基　　金：国家自然科学基金面上项目(82274612);河南省自然科学基金面上项目(222300420483);河南省中医药科学研究专项课题重点项目(2024ZY1031)。

摘　　要：阿尔茨海默病(AD)起病隐匿,近年来研究发现线粒体-内质网偶联结构(MAMs)参与调控磷脂代谢、钙信号转导与线粒体功能等多种细胞过程,与AD发生发展密切相关。中医认为肾主藏精,精生髓,髓生脑,肾气虚是AD的根本病机,肾气不足则能量不充,从而发生代谢失调,这与MAMs介导的功能紊乱病理机制存在高度契合性。因此,通过阐述MAMs功能与中医“肾气”在AD中的相似性,从整体揭示AD从肾论治靶向MAMs调节异常的机制,为理解从肾论治的现代科学内涵和干预AD治疗挖掘新思路。Alzheimer′s disease(AD)has a subtle onset,and recent studies have found that mitochondria-endoplasmic reticulum structure coupling(mitochondrial-associated endoplasmic reticulum membranes,MAMs)play a role in regulating various cellular processes,including phospholipid metabolism,calcium signaling,and mitochondrial function,all of which are closely linked to the onset and progression of AD.Traditional Chinese medicine(TCM)believes that the kidney is responsible for storing essence,which produces marrow,and marrow nourishes the brain.Kidney qi deficiency is considered the fundamental pathogenesis of AD,as insufficient kidney qi leads to energy depletion,resulting in metabolic disorders.This mechanism closely aligns with the pathological disruptions mediated by MAMs.Therefore,by exploring the functional similarities between MAMs and TCM concept of“kidney qi”in AD,this study aims to provide a holistic approach to the treatment of AD from the perspective of kidney and target MAMs regulation,offering new insights into the modern scientific interpretation and potential interventions for AD treatment from the kidney.

关 键 词：阿尔茨海默病 线粒体-内质网偶联结构 能量代谢 肾精肾气 补肾方药 研究进展 科学内涵 中医 

分 类 号：R277.7[医药卫生—中医学]