金合欢素抗肿瘤作用研究进展  

Research Progress on Antitumor Effects of Acacetin

作　　者：周诚 崔梦娇 俞雪 蒋霆辉[1] 孙贤俊 刘艳[1,4] ZHOU Cheng;CUI Mengjiao;YU Xue;JIANG Tinghui;SUN Xianjun;LIU Yan(Oncology Interventional Department of Integrated Chinese and Western Medicine,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Integrated Traditional Chinese and Western Medicine,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China;Interventional Cancer Institute of Chinese Integrative Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)

机构地区：[1]上海中医药大学附属普陀医院中西医结合肿瘤介入科,上海200062 [2]上海中医药大学,上海201203 [3]复旦大学附属华山医院中西医结合科,上海200040 [4]上海中医药大学中西医结合肿瘤介入研究所,上海200062

出　　处：《世界中医药》2024年第24期3865-3873,共9页World Chinese Medicine

基　　金：国家自然科学基金项目(82374377);上海市卫健委青年人才项目(2022YQ037);普陀区科技创新项目(ptkwws202210);上海市普陀区中心医院“临床匠才”人才项目(2022-RCJC-07)。

摘　　要：金合欢素是一种广泛存在于植物和膳食中的天然黄酮,具有抑菌、抗炎、抗氧化、抗病毒等多种药理学作用,在心脏损伤、肺损伤、肝脏损伤等病理状态也具有治疗潜力。近年来研究发现,金合欢素可作为一种抗肿瘤活性成分在肝癌、非小细胞肺癌、前列腺癌和乳腺癌等多种肿瘤中发挥抗癌效应,其作用机制主要包括抑制肿瘤细胞增殖、侵袭和迁移,诱导肿瘤细胞凋亡,控制肿瘤血管生成,阻滞肿瘤细胞周期,逆转耐药及药效增敏等。Acacetin is a natural flavonoid widely found in plants and dietary sources,with a range of pharmacological actions,including antibacterial,anti-inflammatory,antioxidant,and antiviral effects.It also holds therapeutic potential in conditions such as cardiac injury,lung damage,and liver injury.Recent studies have revealed that acacetin possesses antitumor activity in various cancers,including liver cancer,non-small cell lung cancer,prostate cancer,and breast cancer.Its mechanisms of action mainly include inhibiting tumor cell proliferation,invasion,and migration,inducing apoptosis in tumor cells,controlling tumor angiogenesis,blocking the tumor cell cycle,reversing drug resistance,and enhancing drug efficacy.

关 键 词：金合欢素 增殖 侵袭 转移 坏死性凋亡 细胞周期 抗血管生成 肿瘤耐药 免疫调节 

分 类 号：R285[医药卫生—中药学]