化橘红化学成分、药理作用及毒理学研究进展  

Research Progress on Chemical Components,Pharmacological Effects,and Toxicology of Citri Grandis Exocarpium

作　　者：邹慕菡 吴灏 胡双飞 钟梦丽 苏薇薇[1] 李沛波[1] ZOU Muhan;WU Hao;HU Shuangfei;ZHONG Mengli;SU Weiwei;LI Peibo(Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed Traditional Chinese Medicine,Guangdong Key Laboratory of Plant Resources,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China)

机构地区：[1]中山大学生命科学学院,广东省中药上市后质量与药效再评价工程技术研究中心/广东省热带亚热带植物资源重点实验室,广州510275

出　　处：《世界中医药》2024年第24期3889-3897,共9页World Chinese Medicine

基　　金：国家自然科学基金面上项目(82004043);广东省自然科学基金面上项目(2023A1515011953);岭南现代农业科学与技术广东省实验室茂名分中心基金资助课题(2022ZD006)。

摘　　要：化橘红化学成分主要包括黄酮类化合物、挥发油、多糖、香豆素类化合物、无机元素和肌醇等。现代药理学研究表明,化橘红及其化学成分具有止咳、祛痰、平喘、降血糖、降血脂、抗癌、抗病毒、抗肝损伤、抗心肌损伤、抗肺纤维化、抗肺动脉高压、神经保护、抗血栓、抗氧化、抗炎、免疫调节等药理活性。毒理学研究证实其安全性良好。The chemical composition of Citri Grandis Exocarpium mainly includes flavonoids,volatile oils,polysaccharides,coumarin compounds,inorganic elements,and inositol.Modern pharmacological studies have shown that Citri Grandis Exocarpium and its chemical components possess a variety of pharmacological activities,including antitussive,expectorant,antiasthmatic,hypoglycemic,hypolipidemic,anticancer,antiviral,hepatoprotective,cardioprotective,anti-pulmonary fibrosis,anti-pulmonary hypertension,neuroprotective,antithrombotic,antioxidant,anti-inflammatory,and immunomodulatory effects.Toxicological studies have confirmed its good safety profile.

关 键 词：化橘红 化学成分 药理作用 毒理学研究 作用机制 开发利用 研究进展 综述 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]