肠道菌群与胃食管反流病的相关性研究进展  

Research Progress on the Correlation Between Gut Microbiota and Gastroesophageal Reflux Disease

作　　者：魏秀秀 张北华[2] 马祥雪 尹晓岚 刘佳丽 徐陆周[1] 唐旭东[2] WEI Xiuxiu;ZHANG Beihua;MA Xiangxue;YIN Xiaolan;LIU Jiali;XU Luzhou;TANG Xudong(Jiangsu Province Hospital of Chinese Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;Institute of Digestive Diseases,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]江苏省中医院/南京中医药大学附属医院,南京210029 [2]中国中医科学院西苑医院脾胃病研究所,北京100091

出　　处：《世界中医药》2024年第24期3903-3908,共6页World Chinese Medicine

基　　金：国家重点研发计划项目(2019YFC1709600);国家自然科学基金青年项目(82004356);国家中医药传承创新团队及人才支持计划项目(ZYYCXTD-C-202010);江苏省中医院优秀青年博士培养计划项目(2024QB040);第五批全国中医临床优秀人才研修项目(国中医药人教函〔2022〕1号)。

摘　　要：肠道菌群作为人类的第二基因组,与人类健康和疾病息息相关,正在成为影响人类健康和疾病的关键参与者。胃食管反流病(GERD)是一种常见的慢性消化系统疾病,可以引起肠道菌群改变。越来越多的研究表明,肠道菌群影响GERD发展的炎症反应介导的黏膜屏障、胃肠动力、内脏高敏感等,可通过粪菌移植、微生态制剂以及中医药疗法以调节肠道菌群,将肠道菌群作为GERD干预靶点。The gut microbiota,as the second genome of humans,is closely related to human health and diseases,and is becoming a key participant in influencing human health and disease.Gastroesophageal reflux disease(GERD)is a common chronic digestive system disorder that can lead to alterations in the gut microbiota.Increasing research shows that the gut microbiota affects the development of GERD through mechanisms such as inflammatory response-mediated mucosal barrier disruption,gastrointestinal motility,and visceral hypersensitivity.Interventions like fecal microbiota transplantation,microbiome-based preparations,and traditional Chinese medicine therapies can regulate the gut microbiota,positioning it as a potential target for GERD intervention.

关 键 词：肠道菌群 胃食管反流病 黏膜屏障 胃肠动力 内脏高敏感 研究进展 中医药 炎症反应 

分 类 号：R259[医药卫生—中西医结合]