三发性甲状旁腺功能亢进症研究进展  

Research progress in tertiary hyperparathyroidism

作　　者：王秀川 王兆军[2] WANG Xiu-chuan;WANG Zhao-jun(Department of Nephrology,Jinan Fourth People's Hospital,Jinan 250031,China;Department of Pharmacy Jinan Fourth People's Hospital,Jinan 250031,China)

机构地区：[1]济南市第四人民医院肾内科,济南250031 [2]济南市第四人民医院药学部,济南250031

出　　处：《中国血液净化》2025年第2期145-148,共4页Chinese Journal of Blood Purification

基　　金：济南市卫生健康委员会科技计划项目(2024301010)。

摘　　要：三发性甲状旁腺功能亢进症(tertiary hyperparathyroidism,THPT)是在长期继发性甲状旁腺功能亢进症(secondary hyperparathyroidism,SHPT)的基础上发展而来,其特征是甲状旁腺激素(PTH)自主分泌,血清钙水平升高,通常发生在肾移植后。THPT会增加骨折的风险,促进冠状动脉钙化,并是影响肾移植受者的重要因素;手术是THPT的首选治疗方法,但部分患者因未能及时识别并诊断该病而错过了最佳手术时机。为提高对THPT的认识,本文综述了THPT的发病机制、临床表现、影像学特点、诊断和治疗方面的最新进展。Tertiary hyperparathyroidism(THPT)develops on the basis of long-standing secondary hyperparathyroidism(SHPT),characterized by autonomous secretion of parathyroid hormone(PTH)and elevated serum calcium level,and typically happens after kidney transplantation.THPT can lead to the risks of bone fracture and coronary artery calcification,and is an important factor affecting the recipients of renal transplantation.Surgery is the preferable treatment for THPT.However,some patients lose the optimal period of surgical treatment due to delayed diagnose of THPT.This article reviews recent advances in pathogenesis,clinical manifestations,imaging characteristics,diagnosis,and treatment of THPT in order to improve our knowledge about THPT.

关 键 词：三发性甲状旁腺功能亢进 甲状旁腺激素 肾移植 甲状旁腺切除术 

分 类 号：R582.1[医药卫生—内分泌]