低分子肝素治疗辅助生殖技术获得妊娠后复发性流产效果的Meta分析  

Meta-analysis of the efficacy of low molecular heparin in the treatment of recurrent spontaneous abortion after pregnancy by assisted reproductive technology

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作  者:张虎 ZHANG Hu(Office of Party and Government Affairs,Xintai People's Hospital,Tai'an,Shandong 271200,China)

机构地区:[1]新泰市人民医院党政办公室,山东泰安271200

出  处:《医药前沿》2025年第6期12-16,共5页Journal of Frontiers of Medicine

摘  要:目的系统性分析低分子肝素治疗辅助生殖技术(ART)获得妊娠后复发性流产(RSA)的效果。方法检索中国知网、维普网、PubMed、万方数据知识服务平台等电子数据库,查找低分子肝素治疗ART获得妊娠后RSA效果比较的随机对照试验(RCT),检索时间均从建库至2024年6月。由2位研究者进行资料提取及质量评价,采用RevMan 5.3软件进行Meta分析。结果共纳入9项研究724例患者,其中试验组采用低分子肝素联合宫腔内人工授精方式361例,对照组采用单一宫腔内人工授精方式363例。Meta分析结果显示,试验组妊娠成功数、妊娠高血压例数、再次流产发生例数及再发RSA妊娠时间均优于对照组,差异有统计学意义(P<0.05)。结论低分子肝素治疗ART获得妊娠后RSA的临床效果明显,可提高妊娠率,改善妊娠结局。Objective To systematically analyze the efficacy of low molecular heparin in the treatment of recurrent spontaneous abortion(RSA)after pregnancy by assisted reproductive technology(ART).Methods The randomized controlled trials(RCT)about comparing the effects of low molecular heparin in the treatment of RSA after pregnancy by ART were searched through electronic databases such as CNKI,Vip,PubMed and Wanfang Data.The retrieval time was from establishment of the database to June 2024.Data extraction and quality evaluation were conducted by two researchers,and Meta-analysis was performed by using RevMan 5.3 software.Results A total of 724 patients in 9 studies were included in this study.Among them,361 patients in the experimental group were treated with low molecular heparin combined with intrauterine artificial insemination,while 363 patients in the control group were treated with single intrauterine artificial insemination.Meta-analysis showed that the number of successful pregnancy,the number of patients with gestational hypertension,the number of patients with recurrent abortion and the time of recurrent RSA pregnancy in the experimental group were better than those in the control group,and the differences were statistically significant(P<0.05).Conclusions Low molecular heparin in the treatment of RSA after pregnancy by ART has obvious clinical efficacy,and it can improve the pregnancy rate and the pregnancy outcome.

关 键 词:流产 复发性流产 低分子肝素 辅助生殖技术 妊娠 系统评价 META分析 

分 类 号:R714[医药卫生—妇产科学]

 

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