血栓模拟物机械性能及切削破碎效果研究  

Research on Mechanical Properties and Cutting Fragmentation Effectiveness of Thrombus Analogs

作　　者：洪丽 吴重军 李景文 陈令文 沈斌 丁庆伟 HONG Li;WU Chongjun;LI Jingwen;CHEN Lingwen;SHEN Bin;DING Qingwei(College of Mechanical Engineering,Donghua University,Shanghai,201620;Zhejiang Tsinghua Yangtze River Delta Research Institute,Jiaxing,Zhejiang,314000;Shanghai First People s Hospital Affiliated with Shanghai Jiao Tong University School of Medicine,Shanghai,200080)

机构地区：[1]东华大学机械工程学院,上海201620 [2]浙江清华长三角研究院,嘉兴314000 [3]上海交通大学医学院附属第一人民医院,上海200080

出　　处：《中国机械工程》2025年第2期342-350,共9页China Mechanical Engineering

基　　金：上海交通大学医工交叉项目(YG2024QNB18);浙江省自然科学基金(LY23E050002)。

摘　　要：主要对血栓模拟物中红细胞比容进行分析,研究血栓模拟物的机械性能及切削效果。制备了不同红细胞比容的体外血栓模拟物,通过压缩实验研究其机械性能,并结合血栓切削实验装置研究切削速度对其切削效果的影响。研究发现,模拟物的刚度会随着红细胞比容及储存时间的增加而降低;同时,以血清为储存介质保存10 d时,刚度会下降50%以上,而以生理盐水为储存介质保存相同时间,刚度降幅约为30%;另外,10%~20%红细胞比容模拟物与人体深静脉血栓样本刚度相近。实验结果也表明,切削速度在一定范围内提高时有助于对模拟物进行充分破碎,当切削速度过大时破碎效果几乎不再变化。研究结果可为血栓清除器械的设计与优化提供重要参考。The hematocrit of thrombus analogs were analyzed primarily,their mechanical properties and cutting effectiveness were studied.Different hematocrit thrombus analogs were prepared to investigate their mechanical properties through compression tests,and their cutting efficiency was studied using a thrombus cutting experimental setup.It is found that the stiffness of the analogs decreases with increasing hematocrit and storage time.Specifically,when stored in serum for 10 days,stiffness decreases by over 50%,whereas with saline storage over the same period,the decrease is around 30%.Additionally,thrombus analogs with hematocrits of 10%to 20%exhibite stiffness levels similar to samples of deep vein thrombosis.The experiments also indicate that increasing cutting speed within a certain range the fragmentation of the analogs is enhanced,but beyond a certain threshold,further increases in cutting speed does not significantly improve fragmentation.This paper provides valuable insights for the design and optimization of thrombectomy devices.

关 键 词：血栓 机械性能 血栓切削破碎效果 机械血栓清除术 

分 类 号：TG156[金属学及工艺—热处理]