代谢功能障碍相关脂肪性肝病中蛋白乙酰化修饰的研究进展  

Research progress of acetylation in the pathogenesis of MASLD

作　　者：颜利 居峰禹 沈新 于烨 王文辉 YAN Li;JU Fengyu;SHEN Xin;YU Ye;WANG Wenhui(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198;School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学基础医学与临床药学学院,南京211198 [2]中国药科大学药学院,南京211198

出　　处：《中国药科大学学报》2025年第1期31-39,共9页Journal of China Pharmaceutical University

基　　金：国家自然科学基金项目(No.81902480);湖南省“湖湘”高层次人才聚集工程项目(2021RC5013)。

摘　　要：代谢功能障碍相关脂肪性肝病(metabolic dysfunction-associated steatotic liver disease,MASLD)是全球最常见的慢性肝病病因,其发病机制复杂,导致新药研发困难。蛋白乙酰化修饰作为一种常见的翻译后修饰,参与调控蛋白质稳定性、酶活性及其亚细胞定位,广泛发生于MASLD相关的脂质代谢、炎症反应和氧化应激等病理生理过程。本文对相关蛋白质乙酰化修饰异常改变在MASLD中的作用机制进行了综述,分析了基因表达数据库(gene expression omnibus,GEO)中MASLD患者肝组织中(去)乙酰化酶的表达水平并讨论了相关酶在动物模型的表达变化及作用机制,进一步探讨了靶向蛋白乙酰化修饰治疗MASLD的可行性,为MASLD药物研发提供新思路。Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most prevalent cause of chronic liver disease worldwide,and its intricate pathogenesis presents challenges in the development of new drugs.As a common way of post-translational modification,acetylation regulates protein stability,enzyme activity,and subcellular localization,occurring extensively in MASLD-associated processes such as lipid metabolism,inflammatory response,and oxidative stress.In this paper,we comprehensively review the mechanism of acetylation in MASLD,analyze the expression levels of acetylases in liver tissues of MASLD patients from the gene expression omnibus(GEO),discuss the changes in relevant enzyme expression and mechanisms in animal models,and further explore the feasibility of targeting acetylation for MASLD treatment,in the hope of offering a new perspective for advancing drug discovery in the field of MASLD.

关 键 词：代谢功能障碍相关脂肪性肝病 代谢功能障碍相关脂肪性肝炎 乙酰化 乙酰化酶 

分 类 号：R915[医药卫生—微生物与生化药学]