化学改性对透明质酸生物学性质的影响  

Effect of chemical modification on biological properties of hyaluronic acid

作　　者：贾悦 张恒川 赵媛媛 尹少平 殷婷婕 JIA Yue;ZHANG Hengchuan;ZHAO Yuanyuan;YIN Shaoping;YIN Tingjie(School of Pharmacy,China Pharmaceutical University,Nanjing 210009;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023;Hebei Institute for Drug and Medical Device Control,Shijiazhuang 050200,China)

机构地区：[1]中国药科大学药学院,南京210009 [2]南京中医药大学药学院,南京210023 [3]河北省药品医疗器械检验研究院,石家庄050200

出　　处：《中国药科大学学报》2025年第1期119-124,共6页Journal of China Pharmaceutical University

基　　金：国家自然科学基金项目(No.81972835,No.82003305)。

摘　　要：透明质酸(hyaluronicacid,HA)具有良好的生物相容性、生物可降解性和非免疫原性,且对CD44等受体具有主动靶向性。因此,近年来HA已成为设计和制备药物递送载体的重要材料。HA富含可供化学改性的功能团,但不同修饰方法和修饰位点可影响其生物学特性。本文结合HA生物学性质的产生机制、以及其衍生化方法和表征手段深入总结和讨论化学改性对HA生物学性质的影响,为合理的HA化学改性研究提供参考。Hyaluronic acid(HA)possesses excellent biocompatibility,biodegradability,and non-immunogenicity,and exhibits active targeting capability to receptors such as cluster of differentiation 44(CD44).Therefore,HA has become an important material for the design and preparation of drug delivery carriers in recent years.HA is rich in functional groups that can be chemically modified,but different modification methods and sites can affect its biological properties.This paper summarizes and discusses the effects of chemical modification on the biological properties of HA based on the formation mechanisms of such properties,as well as the derivatization and characterization methods of HA,so as to provide some reference for rational research on chemical modification of HA.

关 键 词：透明质酸 化学改性 生物学特性 

分 类 号：R945[医药卫生—微生物与生化药学]