Long non-coding RNAs as promising targets for controlling disease vector mosquitoes  

作　　者：Yujiao Han Qian Pu Ting Fan Tianqi Wei Yankun Xu Lu Zhao Shiping Liu 

机构地区：[1]State Key Laboratory of Resource Insects,Southwest University,Chongqing,400716 China

出　　处：《Insect Science》2025年第1期24-41,共18页昆虫科学(英文版)

基　　金：supported by the National Natural Science Foundation of China(32172797);Chongqing Science and Technology Plan Project(2022NSCQMSX5897);Chongqing Graduate Student Research Innovation Project(CYB21132,CYS22254 and CYS23241);Fundamental Research Funds for the Central Universities(SWU-XJPY202309).

摘　　要：Hematophagous female mosquitoes are important vectors of numerous devastating human diseases,posing a major public health threat.Effective prevention and control of mosquito-borne diseases rely considerably on progress in understanding the molecular mechanisms of various life activities,and accordingly,the molecules that regulate the various life activities of mosquitoes are potential targets for implementing future vector control strategies.Many long non-coding RNAs(lncRNAs)have been identified in mosquitoes and significant progress has been made in determining their functions.Here,we present a comprehensive overview of the research advances on mosquito lncRNAs,including their molecular identification,function,and interaction with other non-coding RNAs,as well as their synergistic regulatory roles in mosquito life activities.We also highlight the potential roles of competitive endogenous RNAs in mosquito growth and development,as well as in insecticide resistance and virus–host interactions.Insights into the biological functions and mechanisms of lncRNAs in mosquito life activities,viral replication,pathogenesis,and transmission will contribute to the development of novel drugs and safe vaccines.

关 键 词：competitive endogenous RNAs(ceRNAs) insecticide resistance long noncoding RNA(lncRNA) MOSQUITO mosquito-borne diseases pathogen-host interaction 

分 类 号：R73[医药卫生—肿瘤]