miR-2940-1 is involved in the circadian regulation of oviposition in Aedes albopictus  

作　　者：Xiaolin Xiao Ling Kong Zhensheng Xie Hongkai Liu Lijun Cai Siyu Zhao Jiayong Zhou Shuang Liu Jing Wu Yiming Wu Peilin Wu Anthony A.James Xiao-Guang Chen 

机构地区：[1]Department of Pathogen Biology,Institute of Tropical Medicine,School of Public Health,Southern Medical University,Guangzhou,China [2]Department of Microbiology&Molecular Genetics,University of California,Irvine,CA,USA [3]Department of Molecular Biology&Biochemistry,University of California,Irvine,CA,USA

出　　处：《Insect Science》2025年第1期69-79,共11页昆虫科学(英文版)

基　　金：supported by grants from the Key R&D Program of Guangdong Province(2022B1111030002);the National Natural Science Foundation of China(31830087 and 82261128003/2022YFML1001);the National Institutes of Health,USA(AI136850)to X.-G.C.A.A.J.is a Donald Bren Professor at the University of California,Irvine.

摘　　要：The vast majority of all global species have circadian rhythm cycles that allow them to adapt to natural environments.These regular rhythms are regulated by core clock genes and recent studies have also implicated roles for microRNAs in this regulation.Oviposition is an important circadian behavior in the reproductive cycle of insect vectors of diseases,and little is known about the rhythm or its regulation in mosquitoes.Aedes albopictus is a diurnal mosquito that transmits arboviruses and is the major cause of outbreaks of dengue fever in China.We analyzed the oviposition rhythm patterns of A.albopictus under different light/dark conditions and show that the mosquitoes have an oviposition peak between zeitgeber time 9(ZT 9)and ZT 12.Furthermore,the antagomir-mediated knockdown of expression of the microRNA miR-2940-1 affected the oviposition rhythm of A.albopictus.These data support the conclusion that miR-2940-1 is involved in the regulation of oviposition rhythm in A.albopictus and provide a foundation for using oviposition rhythms as a new target for vector mosquito control.

关 键 词：Aedes albopictus miR-2940-l oviposition rhythm REGULATION 

分 类 号：R73[医药卫生—肿瘤]