手性酰胺导向基在不对称碳氢活化反应中的应用  

The application of chiral amide directing group in asymmetric C–H activation

作　　者：陈文坤 汪君 Wenkun Chen;Jun Wang(School of Chemistry,Sun Yat-sen University,Guangzhou 510006,China)

机构地区：[1]中山大学化学学院,广州510006

出　　处：《中国科学:化学》2025年第2期370-383,共14页SCIENTIA SINICA Chimica

基　　金：国家重点研发计划(编号:2022YFA1504303);广东省高等学校功能分子工程基础研究卓越中心资助项目。

摘　　要：手性导向基策略是实现过渡金属催化不对称碳氢活化反应的有效途径.其优点是手性原料简单易得,操作简单易行,可避免使用手性催化剂,且手性产物的纯化也较为方便.本综述总结了手性酰胺导向基辅助的不对称碳氢活化反应的研究进展.根据手性酰胺导向基在反应过程中是否发生自动移除,可分为非自移除型和自移除型.本文将分别介绍他们在不对称碳氢活化反应中的应用,并对相关反应机理进行探讨.最后对该领域的发展进行总结和展望.The chiral directing group strategy is an effective way to achieve transition metal-catalyzed asymmetric C–H activation reactions.The advantages include the good availability of chiral reagents,easy operation,avoidance of chiral catalysts,and easy purification of chiral products.This review summarizes the research progress of asymmetric C–H activation reactions assisted by chiral amide directing groups that can be classified into non-self-removing and selfremoving types according to whether they undergo automatic removal during the reaction.In this review,their applications in asymmetric C–H activation will be introduced respectively,and the related reaction mechanisms will be discussed.Finally,the development of the field will be summarized and prospected.

关 键 词：不对称碳氢活化 过渡金属催化 手性酰胺导向基 

分 类 号：O621.251[理学—有机化学]