知母-黄柏药对在性早熟中的临床应用研究  

Research on the clinical application of Zhimu-Huangbai in precocious puberty

作　　者：陈娜 李连科 卢以红 杨洋 陶琼 陈竹 CHEN Na;LI Lianke;LU Yihong;YANG Yang;TAO Qiong;CHEN Zhu(Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China;Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学第二附属医院儿科,贵阳550003 [2]贵州中医药大学第二临床医学院,贵阳550025

出　　处：《中国中西医结合儿科学》2025年第1期8-12,共5页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：贵州省卫生健康委科学技术基金项目(gzwkj2022-400);贵州中医药大学大学生创新创业训练计划项目(贵中医大创合字[2023]17号)。

摘　　要：知母-黄柏在临床过程中是常用的药对,二药配伍具有滋阴清热、泻火解毒功效。现代研究发现,知母-黄柏药对富含槲皮素、山柰酚、巴马汀、豆甾醇、芒果苷、小檗碱等主要活性成分,具有抗炎、抗氧化、降血糖、调血脂等作用。临床应用广泛,主要用于治疗儿童性早熟、糖尿病、糖尿病肾病等疾病。笔者通过从化学成分、药理作用、临床应用角度出发,阐述近年来知母-黄柏在性早熟方面的应用研究,以期为该药对在性早熟方面的科学应用及新药研发提供理论依据。Zhimu-Huangbai is a commonly used medicine pair in clinical practice,and the compatibility of the two drugs has the effects of nourishing yin and clearing heat,purging fire and detoxifying.Modern studies have found that Zhimu-Huangbai has anti-inflammatory,antioxidant,hypoglycemic,and lipidemic regulation effects because of its main active ingredients such as quercetin,kaempferol,barmatine,stigmasterol,mangiferin,berberine,etc.It is widely used in clinical practice,mainly for the treatment of precocious puberty,diabetes,diabetic nephropathy and other diseases in children.From the perspectives of chemical composition,pharmacological effects and clinical application,this paper expounds the application research of Zhimu-Huangbai in precocious puberty in recent years,in order to provide a theoretical basis for the scientific application of the drug in precocious puberty and for the research and development of new drugs.

关 键 词：性早熟 知母-黄柏 活性成分 临床应用研究 儿童 

分 类 号：R725.8[医药卫生—儿科]