不同年龄段儿童高尿酸血症危险因素分析  

Analysis of risk factors for hyperuricemia in children of different ages

作　　者：方艳莹 甘嘉慧 徐钰茵 徐梓莹 司徒美玲 余淑娟 FANG Yanying;GAN Jiahui;XU Yuyin;XU Ziying;SITU Meiling;YU Shujuan(Kaiping City Centre Hospital,Kaiping 529300,China;Kaiping Maternal and Child Health Hospital,Kaiping 529300,China)

机构地区：[1]开平市中心医院儿内科,广东开平529300 [2]开平市中心医院保健科,广东开平529300 [3]开平市妇幼保健院儿科

出　　处：《中国中西医结合儿科学》2025年第1期45-49,共5页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：江门市医疗卫生领域科技计划项目(2022YL10009)。

摘　　要：目的检测不同年龄段儿童(0~14岁)血尿酸水平,调查其地区的高尿酸发生率以及分析其与性别、年龄、体型-体质量指数以及生活习惯[包括进食海鲜,进食老火汤/炖汤,进食蔬菜,进食饮料,进食甜食,每日饮水量(mL),每天的运动量(min)等]的关系。方法对2022年1月至2023年9月开平市中心医院及开平市妇幼保健院就诊的1209例儿童作为研究对象,测量身高/身长、体质量、血尿酸进行检测,按不同年龄及性别进行分组,调查不同年龄组及不同性别儿童血尿酸水平,并根据血尿酸水平进行分组,分析该地区的尿酸现况以及高尿酸血症的发生率,同时探讨高尿酸血症儿童其与性别、年龄、体型-体质量指数以及生活习惯的关系。结果血尿酸在不同性别中的分布差异无统计学意义(P>0.05),在不同年龄、体型的儿童中,血尿酸水平出现随年龄、体型增长而逐渐增高的趋势。高尿酸血症总检出率为20.18%(244/1209),不同性别高尿酸血症检出率比较差异无统计学意义(P>0.05);不同年龄、体型高尿酸血症检出率比较,差异有统计学意义(P<0.01)。Logistic回归分析结果显示,进食海鲜、进食饮料及喜好甜食是引起高尿酸血症的危险因素,增加蔬菜的进食、饮水量以及适当的运动量是尿酸的保护因素。结论开平市地区儿童的血尿酸水平随着年龄增长及体型改变有所增高,与性别无特定关系,高嘌呤及高糖食物是引起高尿酸血症的危险因素。Objective To measure serum uric acid(SUA)levels in children of different ages(0 to 14 years),investigate the incidence of high level of uric acid in those regions,and analyze its association with gender,age,body size-body mass index(BMI),and living habits[including consumption of seafood,consumption of long-boiled soup/stew,consumption of vegetables,consumption of beverages,consumption of sweets,daily water intake(mL)and daily exercise(min)].Methods Totally 1209 children visiting Kaiping City Centre Hospital and Kaiping Maternal and Child Health Hospital from January 2022 to September 2023 were enrolled in the study.Height/length,weight and SUA of the children were measured,and the children were grouped according to age and gender in order to investigate the SUA levels of children in different age groups and genders.In addition,the children were grouped according to the SUA level to investigate the current situation of uric acid and the incidence of hyperuricaemia in the region.In the meantime,the relationship between hyperuricaemia(HUA)in the children and their gender,age,body size-BMI and living habits were also investigated.Results The distribution of SUA levels showed no statistically significant difference between different genders(P>0.05).In children of different ages and body types,SUA levels exhibited a trend of gradual increase with age and body type growth.The overall detection rate of hyperuricemia was 20.18%(244/1209),and the comparison of the detection rates of hyperuricemia between different genders showed no statistically significant difference(P>0.05).However,the comparison of hyperuricemia detection rates among different ages and body types showed statistically significant differences(P<0.01).Logistic regression analysis revealed that seafood consumption,beverage intake,and a preference for sweet foods were risk factors for hyperuricemia,while increased vegetable intake,fluid consumption,and appropriate exercise were protective factors for uric acid levels.Conclusion The level of SUA in children

关 键 词：高尿酸 发生率 影响因素 儿童 

分 类 号：R725.8[医药卫生—儿科]