小儿定喘颗粒干预呼吸道合胞病毒肺炎(痰热闭肺证)的临床疗效观察  

Observation on the clinical efficacy of Xiaoer Dingchuan granule in the intervention of respiratory syncytial virus pneumonia(syndrome of phlegm-heat blocking the lung)

作　　者：李瑞雪 王雪峰[2] 谭春迎[3] 孟斌 张秀英[2] 王辉[1] 李兆洋 LI Ruixue;WANG Xuefeng;TAN Chunying;MENG Bin;ZHANG Xiuying;WANG Hui;LI Zhaoyang(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Liaoning Maternal and Child Health Hospital,Shenyang 110005,China;Benxi Manzu Autonomous County Hospital of Traditional Chinese Medicine,Benxi 117100,China)

机构地区：[1]辽宁中医药大学,沈阳110847 [2]辽宁中医药大学附属医院儿科,沈阳110032 [3]辽宁省妇幼保健院儿科,沈阳110005 [4]本溪满族自治县中医院儿科,辽宁本溪117100

出　　处：《中国中西医结合儿科学》2025年第1期87-91,共5页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：国家中医药传承创新中心重点病种项目(2023-247)。

摘　　要：目的评价小儿定喘颗粒干预儿童呼吸道合胞病毒肺炎(痰热闭肺证)临床疗效。方法选择2023年6月至2024年6月辽宁中医药大学附属医院、辽宁省妇幼保健院、本溪满族自治县中医院收治住院的呼吸道合胞病毒肺炎(痰热闭肺证)患儿72例为研究对象,随机分为对照组和观察组各36例。对照组采取基础治疗,观察组在对照组治疗的基础上,加用小儿定喘颗粒。治疗7 d后比较两组临床疗效、中医证候疗效、单症缓解时间、消失时间和不良反应。结果治疗后观察组临床疗效、中医证候疗效优于对照组;观察组患儿喘息、咳嗽、喉间痰鸣、发热症状缓解时间少于对照组,差异均有统计学意义(P<0.05);观察组未发生不良事件。对照组1例,表现为恶心呕吐,经治后消失。结论小儿定喘颗粒在治疗呼吸道合胞病毒肺炎(痰热闭肺证)应用中具有积极的治疗作用,临床疗效较好,加快症状消失时间,临床应用安全性较高,值得临床推广。Objective To evaluate the clinical efficacy of Xiaoer Dingchuan granule in the intervention of respiratory syncytial virus pneumonia(syndrome of phlegm-heat blocking the lung)in children.Methods A total of 72 children with respiratory syncytial virus pneumonia(syndrome of phlegm-heat blocking the lung)admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Maternal and Child Health Hospital and Benxi Manzu Autonomous County Hospital of Traditional Chinese Medicine from June 2023 to June 2024 were selected as the study subjects,who were randomly divided into control group and observation group with 36 cases in each group.The control group received basic treatment,and the observation group received Xiaoer Dingchuan granule in addition to the treatment for the control group.After 7 days of treatment,the clinical efficacy,TCM syndrome efficacy,single symptom remission time,disappearance time and adverse reactions were compared between the two groups.Results After treatment,the clinical effect and TCM syndrome effect of the observation group were better than those of the control group.The remission time of wheezing,cough,gurgling with sputum and fever in the observation group was shorter than that in the control group,and the differences were statistically significant(P<0.05).No adverse events occurred in the observation group.One case in the control group had nausea and vomiting,which disappeared after treatment.Conclusion Xiaoer Dingchuan granule has a positive therapeutic effect in the treatment of respiratory syncytial virus pneumonia(syndrome of phlegm-heat blocking the lung);the clinical effect is good,accelerating the disappearance of symptoms,and clinical application safety is high,which is worthy of clinical promotion.

关 键 词：呼吸道合胞病毒肺炎 痰热闭肺证 小儿定喘颗粒 儿童 

分 类 号：R725.6[医药卫生—儿科]