急性心肌梗死患者血清TET2、ox-LDL、CLU水平与心室重构及主要心血管不良事件的相关性  

Correlation of serum TET2,ox-LDL,CLU with ventricular remodeling and major adverse cardiovascular events in patients with acute myocardial infarction

作　　者：王青雷 黄贤胜[1] 付珊 李舒承[1] 王虹[1] WANG Qinglei;HUANG Xiansheng;FU Shan;LI Shucheng;WANG Hong(The Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)

机构地区：[1]承德医学院附属医院,河北承德067000

出　　处：《检验医学》2025年第1期49-53,共5页Laboratory Medicine

基　　金：河北省卫生健康委员会重点科研计划项目(20220412)。

摘　　要：目的探讨急性心肌梗死(AMI)患者血清甲基双加氧酶2(TET2)、氧化修饰低密度脂蛋白(ox-LDL)、丛生蛋白(CLU)水平与心室重构和经皮冠状动脉介入(PCI)术后发生主要心血管不良事件(MACE)的关系。方法选取2020年5月—2022年5月承德医学院附属医院AMI患者97例(AMI组)和健康体检者97名(正常对照组)。收集所有研究对象的临床资料,并检测AMI患者PCI术前、正常对照者体检当日血清TET2、ox-LDL、CLU水平和心室重构指标[左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末内径(LVEDD)、左心室质量指数(LVMI)]。对AMI患者进行PCI术后随访1年,根据MACE的发生情况分为MACE组和无MACE组。采用Pearson相关分析评估各项指标之间的相关性。采用受试者工作特征(ROC)曲线评价各项指标判断AMI患者发生MACE的效能。结果与正常对照组比较,AMI组血清ox-LDL、CLU水平和LVEDD、LVESV、LVMI显著升高(P<0.001),血清TET2水平和LVEF显著降低(P<0.001)。AMI组血清ox-LDL、CLU与LVEDD、LVESV、LVMI均呈正相关(P<0.001),与LVEF呈负相关(P<0.001);血清TET2与LVEDD、LVESV、LVMI均呈负相关(P<0.001),与LVEF呈正相关(P<0.001)。与无MACE组比较,MACE组血清ox-LDL、CLU水平升高(P<0.05),血清TET2水平显著降低(P<0.001)。血清TET2、ox-LDL、CLU单项检测和联合检测判断AMI患者发生MACE的曲线下面积(AUC)分别为0.689、0.657、0.664、0.839。结论血清TET2、ox-LDL、CLU水平与AMI患者心室重构和发生MACE密切相关,三者联合检测对AMI患者PCI术后发生MACE有较高的预测价值。Objective To investigate the correlation of serum ten-eleven translocation(TET2),oxidized lowdensity lipoprotein(ox-LDL),clusterin(CLU)with ventricular remodeling and major adverse cardiovascular events(MACE)in patients with acute myocardial infarction(AMI)after ventricular remodeling and percutaneous coronary intervention(PCI).Methods A total of 97 patients with AMI(AMI group)and 97 healthy subjects(healthy control group)were enrolled from the Affiliated Hospital of Chengde Medical College from May 2020 to May 2022.The clinical data of all subjects were collected,and serum TET2,ox-LDL,CLU levels and ventricular remodeling indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic diameter(LVEDD),left ventricular mass index(LVMI)]were determined before PCI.All the patients underwent PCI and were followed up for 1 year.They were classified into MACE group and non-MACE group.Pearson correlation analysis was used to evaluate the correlation among the indexes.Receiver operating characteristic(ROC)curve was used to evaluate the efficacy of various indexes in determining MACE in AMI patients.Results Compared with healthy control group,serum ox-LDL,CLU,LVEDD,LVESV and LVMI in AMI group were increased(P<0.001),and serum TET2 and LVEF were decreased(P<0.001).Serum ox-LDL and CLU in AMI group were positively correlated with LVEDD,LVESV and LVMI(P<0.001),and they were negatively correlated with LVEF(P<0.001).Serum TET2 was negatively correlated with LVEDD,LVESV and LVMI(P<0.001),and it was positively correlated with LVEF(P<0.001).Compared with non-MACE group,serum ox-LDL and CLU in MACE group were increased(P<0.05),and serum TET2 level was decreased(P<0.001).The areas under curves(AUC)of serum TET2,ox-LDL and CLU single and combined determinations for MACE in AMI patients were 0.689,0.657,0.664 and 0.839,respectively.Conclusions Serum TET2,ox-LDL and CLU are related to ventricular remodeling and MACE in AMI patients,and the combined determination of TET2,ox-LD

关 键 词：甲基双加氧酶2 氧化修饰低密度脂蛋白 丛生蛋白 心室重构 主要心血管不良事件 急性心肌梗死 

分 类 号：Q556[生物学—生物化学]