简化肺栓塞严重程度指数联合血尿酸和中性粒细胞百分比对肺癌合并急性肺栓塞患者短期预后的预测  

Predictive value of the simplified pulmonary embolism severity index combined with serum uric acid and neutrophil percentage in the short-term prognosis of lung cancer patients with acute pulmonary embolism

作　　者：严秋梅 张兴 李玉英 YAN Qiumei;ZHANG Xing;LI Yuying(Department of Respiratory and Intensive Care,Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)

机构地区：[1]西南医科大学附属医院呼吸与危重症医学科,四川泸州646000

出　　处：《中国临床研究》2025年第2期196-199,224,共5页Chinese Journal of Clinical Research

基　　金：四川省科技计划项目(2023NSFSC0527)。

摘　　要：目的探讨对肺癌合并急性肺栓塞(APE)患者短期预后的预测中,简化肺栓塞严重程度指数(sPESI)联合血尿酸、中性粒细胞百分比(NEUT%)的应用及价值。方法回顾性选取2019年1月至2022年12月西南医科大学附属医院收治的肺癌合并APE患者102例,根据入院后30 d临床结局分为死亡组和生存组,收集和比较两组患者临床资料和sPESI,分析肺癌合并APE短期预后的影响因素,受试者工作特征(ROC)曲线评估各指标对患者短期预后的预测价值。结果102例肺癌合并APE患者中,死亡组19例,存活组83例。多因素logistic回归分析提示,sPESI(OR=7.055,95%CI:2.124~23.441)及血尿酸、NEUT%是肺癌合并APE患者短期预后的独立影响因素(P<0.05)。ROC曲线分析显示,sPESI预测肺癌合并APE患者短期预后的曲线下面积(AUC)为0.821,血尿酸为0.834,NEUT%为0.791,三者联合为0.937(95%CI:0.892~0.982)。结论sPESI联合血尿酸和NEUT%对肺癌合并APE患者短期预后具有良好的预测价值。Objective To explore the application and value of simplified pulmonary embolism severity index(sPESI)combined with serum uric acid(SUA)and neutrophil percentage(NEUT%)in the prediction of short-term prognosis of lung cancer patients with acute pulmonary embolism(APE).Methods A total of 102 lung cancer patients with APE admitted to the Affiliated Hospital of Southwest Medical University from January 2019 to December 2022 were retrospectively selected,and they were divided into death group and survival group according to the clinical outcome 30 days after admission.The clinical data and sPESI of the patients in the two groups were collected and compared,and the factors affecting the short-term prognosis of lung cancer patients with APE were analyzed,and the predictive value of each index on the short-term prognosis of patients was assessed by the receiver operating characteristic(ROC)curves.Results Among 102 lung cancer patients with APE,19 cases were in the death group and 83 cases were in the survival group.Logistic regression analysis suggested that sPESI(OR=7.055,95%CI:2.124-23.441)and SUA,NEUT%were independent influencing factors for the short-term prognosis of the lung cancer patients with APE(P<0.05).ROC curve analysis showed that the area under the curve(AUC)for predicting the short-term prognosis of lung cancer patients with APE was 0.821 for sPESI,0.834 for SUA,0.791 for NEUT%,and 0.937(95%CI:0.892-0.982)for the combination of the three.Conclusion sPESI combined with SUA and neutrophil percentage has a good predictive value for short-term prognosis in lung cancer patients combined with APE.

关 键 词：肺癌 肺栓塞 尿酸 中性粒细胞百分比 简化肺栓塞严重程度指数 预后 

分 类 号：R563.5[医药卫生—呼吸系统] R734.2[医药卫生—内科学]