Indigo机械血栓清除术治疗急性下肢深静脉血栓形成的疗效  

Efficacy of the Indigo mechanical thrombectomy for the acute deep venous thrombosis of lower extremity

作　　者：田中 田志龙 孙鹏程 秦瑞浩 袁福康 TIAN Zhong;TIAN Zhilong;SUN Pengcheng;QIN Ruihao;YUAN Fukang(Department of Vascular Surgery of Xuzhou Central Hospital,The Affiliated Xuzhou Clinical College of Xuzhou Medical University,Xuzhou,Jiangsu 221009,China)

机构地区：[1]徐州医科大学徐州临床学院徐州市中心医院血管外科,江苏徐州221009

出　　处：《中国临床研究》2025年第2期219-224,共6页Chinese Journal of Clinical Research

基　　金：江苏省自然科学基金(BK20161168);徐州市医学青年后备人才(XWRCHT20220058)。

摘　　要：目的比较Indigo机械血栓清除术和导管接触性溶栓(CDT)治疗急性下肢深静脉血栓形成(DVT)的效果。方法回顾性分析2022年12月至2023年12月徐州市中心医院收治的108例急性下肢DVT患者的临床资料,根据治疗方法不同分为两组。对照组57例患者采用CDT治疗,试验组51例患者采用Indigo机械吸栓治疗,比较两组患者的术后静脉通畅评分、术后静脉通畅率、患肢消肿率、血栓清除分级、尿激酶用量、溶栓时间、住院时间。结果试验组患者术后静脉通畅评分低于对照组[(1.63±1.00)分vs(2.35±1.08)分],静脉通畅率[(78.97±13.04)%vs(68.07±14.25)%]、患肢消肿率[(72.31±11.70)%vs(65.68±8.27)%]高于对照组,差异有统计学意义(P<0.05)。试验组尿激酶用量[(146.08±35.85)万单位vs(308.42±45.33)万单位]少于对照组,溶栓时间[(2.39±0.78)d vs(5.11±0.82)d]、住院时间[(8.37±0.96)d vs(10.37±1.10)d]短于对照组,差异有统计学意义(P<0.05)。两组血栓清除分级比较差异无统计学意义(P>0.05)。随访时间6~18个月,植入支架患者支架均通畅、未发生狭窄与闭塞。结论与CDT相比,Indigo机械清除血栓的治疗方案具有更显著的优势,包括降低溶栓药物的使用量、缩短治疗时间、提高溶栓效果,并且操作简便。Objective To compare the efficacy of Indigo mechanical thrombectomy and catheter-directed thrombolysis(CDT)in the treatment of acute deep vein thrombosis(DVT)of the lower extremity.Methods A retrospective analysis was conducted on the clinical data of 108 patients with acute lower extremity DVT treated at Xuzhou Central Hospital from December 2022 to December 2023.According to the treatment method,patients were divided into two groups.The control group consisted of 57 patients who received CDT treatment,while the experimental group consisted of 51 patients who underwent Indigo mechanical thrombectomy.Postoperative venous patency scores,postoperative venous patency rates,swelling reduction rates of the affected limbs,thrombus clearance grades,dosages of urokinase,thrombolytic times,and hospital stays were compared between the two groups.Results The postoperative venous patency score in the experimental group was lower than that in the control group(1.63±1.00 vs 2.35±1.08),while the venous patency rate[(78.97±13.04)%vs(68.07±14.25)%]and the swelling reduction rate[(72.31±11.70)%vs(65.68±8.27)%]were higher in the experimental group compared to the control group,with statistically significant differences(P<0.05).The dosage of urokinase in the experimental group[(146.08±35.85)×104 units vs(308.42±45.33)×104 units]was lower than in the control group,and the thrombolysis time[(2.39±0.78)days vs(5.11±0.82)days]and hospital stays[(8.37±0.96)days vs(10.37±1.10)days]were shorter in the experimental group,with statistically significant differences(P<0.05).No significant difference was observed between the two groups in terms of thrombus clearance grading(P>0.05).Follow-up time ranged from 6 to 18 months,and all patients with implanted stents had patent stents without any occurrence of stenosis or occlusion.Conclusion Compared to CDT,the Indigo mechanical thrombectomy treatment regimen has more significant advantages,including reducing the use of thrombolytic drugs,shortening treatment time,improving thrombolyti

关 键 词：下肢深静脉血栓形成 血栓抽吸 Indigo机械血栓清除术 导管接触性溶栓 

分 类 号：R543[医药卫生—心血管疾病]