抗炎膳食对超重/肥胖人群新发代谢综合征影响前瞻性队列研究  

A prospective cohort study on the impact of anti-inflammatory diet on the incidence of metabolic syndrome in overweight/obese populations

作　　者：赵辉 迪丽胡玛尔·艾力 罗涛 张泽文[1] 巴合古·依明尼亚孜 顾园申 署丽盼 乔婷婷 戴江红[1] ZHAO Hui;DILIHUMAER Aili;LUO Tao;ZHANG Zewen;BAHEGU Yimingniyazi;GU Yuanshen;SHU Lipan;QIAO Tingting;DAI Jianghong(School of Public Health,Xinjiang Medical University,Urumqi,Xinjiang Uygur Autonomous Region 830017,China;不详)

机构地区：[1]新疆医科大学公共卫生学院,新疆维吾尔自治区乌鲁木齐830017 [2]新疆医科大学护理学院

出　　处：《中国预防医学杂志》2025年第1期8-14,共7页Chinese Preventive Medicine

基　　金：新疆维吾尔自治区自然科学基金资助项目(2022D01C437);国家自然科学基金资助项目(82160640);新疆特殊环境与健康研究重点实验室开放课题资助项目(SKL-SEHR-2021-07);科技创新团队(天山创新团队)项目(2022TSYCTD0013)。

摘　　要：目的分析抗炎膳食对超重/肥胖人群代谢综合征发生的影响,为超重/肥胖人群代谢综合征的预防提供膳食干预依据。方法以2019年新疆维吾尔自治区(新疆)伊犁哈萨克自治区(伊犁州)霍城县招募的超重/肥胖居民为研究对象,进行问卷调查、体格及实验室检查,并于2020年进行随访,通过膳食炎症指数(dietary inflammatory index,DII)和能量调整膳食炎症指数(energy-density dietary inflammatory index,EDII)评价其膳食炎症效应,利用Log-rank和Cox回归分析膳食炎症与代谢综合征发生的关系。结果3315例超重/肥胖者中,无代谢综合征者2233例,其中441例在随访中发生代谢综合征;不同炎症膳食DII和EDII组的代谢综合征发病风险差异有统计学意义(χ^(2)=8.142、10.602,P=0.017、0.005);DII抗炎膳食组(T1组)的代谢综合征发生风险是促炎膳食组(T3)的0.64倍(95%CI:0.46~0.90);EDII抗炎膳食组(T1组)的代谢综合征发生风险是促炎膳食组(T3)的0.61倍(95%CI:0.43~0.86);将DII和EDII作为连续变量分析发现,随着DII或EDII的升高代谢综合征发病风险不断增加(HR=1.21、1.27,95%CI:1.05~1.38、1.07~1.51)。抗炎膳食组的食物特征为低加工谷物和高蔬菜水果摄入。结论抗炎膳食组可通过抗炎效应降低超重/肥胖人群代谢综合征发病风险,增加蔬菜、水果等抗炎食物的摄入可能是预防代谢综合征发生的重要途径。Objective To investigate the effects of an anti-inflammatory diet on the occurrence of metabolic syndrome in overweight/obese individuals,providing dietary intervention guidance for the prevention of metabolism syndrome in this population.Methods Rural residents recruited in Huocheng County,Ili Kazakh Autonomous Prefecture,Xinjiang Uygur Autonomous Region in 2019 were selected as the study objects to conduct questionnaire surveys,physical and laboratory examinations,and a follow-up in 2020.The effects of dietary inflammation were assessed using the dietary inflammatory index(DII)and the energy-adjusted dietary inflammatory index(EDII).The relationships between dietary inflammation and the occurrence of metabolic syndrome were analyzed using Log-rank and Cox regression.Results Among the 3315 overweight/obese individuals,2233 had no metabolic syndrome at baseline,and 441 individuals developed metabolic syndrome during the follow-up.There were statistically significant differences in the risk of developing metabolic syndrome among different inflammatory diet DII and EDII groups(χ^(2)=8.142,10.602,P=0.017,0.005).The risk of developing metabolic syndrome in the anti-inflammatory diet group(T1)was 0.64(95%CI:0.46-0.90)times that of the proinflammatory diet group(T3)for DII and 0.61(95%CI:0.43-0.86)times for EDII.When analyzed as continuous variables,for each unit increase in DII and EDII,the risk of developing metabolic syndrome increased by 1.21(95%CI:1.05-1.38)and 1.27(95%CI:1.07-1.51),respectively.The anti-inflammatory dietary group was characterized by low processed grains and high vegetable and fruit intake.Conclusions The anti-inflammatory dietary group can reduce the risk of developing metabolic syndrome in overweight/obese populations through its anti-inflammatory effects and increasing the intake of anti-inflammatory foods,such as vegetables and fruits,may be an important way to prevent the development of the metabolic syndrome.

关 键 词：抗炎膳食 超重/肥胖 代谢综合征 农村居民 

分 类 号：R181[医药卫生—流行病学]