糖尿病与活动性结核病发病风险关系的Meta分析  

Meta-analysis of the relationship between diabetes mellitus and the risk of active tuberculosis

作　　者：陶荣珊 龙睿禹 雷竣林 詹茜 TAO Rongshan;LONG Ruiyu;LEI Junlin;ZHAN Qian(School of Public Health,Guizhou Medical University,Key Laboratory of Environmental Pollution and Disease Surveillance,Guiyang,Guizhou 550025,China;不详)

机构地区：[1]贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室,贵州贵阳550025 [2]贵州医科大学公共卫生与健康学院

出　　处：《中国预防医学杂志》2025年第1期37-43,共7页Chinese Preventive Medicine

基　　金：贵州省卫生健康委员会项目(gzwkj 2025-379)。

摘　　要：目的系统评价糖尿病与活动性结核病发病风险的相关性,为疾病防控提供依据。方法通过专业检索方式检索PubMed、Embase、Medline、中国生物医学文献数据库、中国知网、万方数据平台及维普中文科技期刊数据库中糖尿病与活动性结核病发病风险相关性的研究文献,检索时限从建库至2022年12月30日。对纳入的文献进行质量评价及数据提取,并应用R4.2.0软件进行Meta分析。结果本研究共纳入22篇文献,涉及27440047例样本。Meta分析结果显示,糖尿病能增加活动性结核病发病风险(RR=1.48,95%CI:1.14~1.92,P<0.01)。亚组分析结果显示,亚洲人群(RR=2.15,95%CI:1.62~2.85)糖尿病患者的活动性结核病发病风险略高于欧洲(RR=1.87,95%CI:1.04~3.36)及大洋洲人群(RR=1.95,95%CI:1.64~2.33);不同诊断方法确诊的糖尿病患者与活动性结核病发病风险也存在一定差异(TR诊断:RR=1.85,95%CI:1.65~2.07;SR诊断:RR=3.12,95%CI:1.51~6.43)。结论糖尿病与活动性结核病发病之间存在关联,糖尿病可能是活动性结核病的危险因素。Objective This study aimed to systematically evaluate the correlation between diabetes and the risk of developing active tuberculosis,to provide basis of disease prevention and control.Methods A comprehensive search was conducted in databases including PubMed,Embase,Medline,China National Knowledge Infrastructure(CNKI),Wanfang Data,and VIP Chinese Journal Database for literature on the relationship between diabetes and the risk of active tuberculosis from the inception of the databases to December 30,2022.The included literature was subjected to quality assessment and data extraction;Meta-analysis was performed using R4.2.0 software.Results A total of 22articles involving 27440047 samples were included.The results of the meta-analysis showed that diabetes could increase the risk of developing active tuberculosis(RR=1.48,95%CI:1.14-1.92,P<0.001).Subgroup analysis indicated that the risk of developing active tuberculosis in diabetic patients was slightly higher in the Asian population(RR=2.15,95%CI:1.62-2.85)is slightly higher than that in Europe(RR=1.87,95%CI:1.04-3.36),and Oceania population(RR=1.95,95%CI:1.64-2.33).Furthermore,there were differences in the risk of developing active tuberculosis among diabetes patients diagnosed by different methods(TR diagnosis:RR=1.85,95%CI:1.65-2.07;SR diagnosis:RR=3.12,95%CI:1.51-6.43).Conclusions There is an association between diabetes and the development of active tuberculosis,suggesting that diabetes may be a risk factor for active tuberculosis.

关 键 词：糖尿病 结核病 风险 META分析 

分 类 号：R587.1[医药卫生—内分泌] R521[医药卫生—内科学]