黄芩素药理特征及缓解污染物毒性效应的作用  

Pharmacological characteristics of baicalein and its role in alleviating the toxic effects of pollutants

作　　者：黄文涛 黄敏毅 张雨豪 HUANG Wentao;HUANG Minyi;ZHANG Yuhao(College of Agriculture and Biotechnology,Hunan University of Humanities,Science and Technology,Loudi 417000,Hunan,China;Key Laboratory of Agricultural Resource Development,Utilisation and Quality and Safety Control of Hunan Characteristics in Hunan Universities,Loudi 417000,Hunan,China)

机构地区：[1]湖南人文科技学院农业与生物技术学院,湖南娄底417000 [2]湘中特色农业资源开发利用与质量安全控制湖南省高校重点实验室,湖南娄底417000

出　　处：《生态学杂志》2025年第2期627-636,共10页Chinese Journal of Ecology

基　　金：国家自然科学基金项目(31970494);湖南省自然科学基金项目(2022JJ30313);湖南省科技创新团队项目(201937924)资助。

摘　　要：由于工业与农业的快速发展,大量的环境污染物被排放到自然环境中,造成动物器官的损伤及疾病发生率的增加等不良效应。黄芩素主要提取于唇形科植物黄芩的根部,是一种黄酮类物质,可通过多种途径对生物体起到治疗与修复作用,在一定程度上缓解污染物的毒性效应。本文概述了黄芩素的抗氧化应激、抗炎、抗病毒病菌及调控细胞凋亡等药理学特征,归纳总结了黄芩素对动物肠道、心脏、肝、肾、肺和神经系统等的解毒作用及机理。黄芩素作为一种潜在解毒剂与治疗剂,具有副作用小和解毒作用强等特点,在修复环境污染物诱导的器官损伤或慢性疾病中具有重要的潜在价值和广泛的应用前景。Due to the rapid development of industry and agriculture,a large number of environmental pollutants have been released into the environment,resulting in adverse effects such as the damage to animal organs and in⁃creasing incidence of disease.Baicalein is mainly extracted from the roots of Scutellaria baicalensis.Baicalein is a flavonoid that can play a therapeutic and restorative role in organisms through various pathways.Moreover,it can alleviate the toxic effects of pollutants.In this paper,we outlined the pharmacological functions of baicalein,such as anti⁃oxidative stress,anti⁃inflammation,anti⁃viral pathogens and regulation of apoptosis.The detoxification effects and mechanisms of baicalein on the intestine,heart,liver,kidney,lung,and the nervous system of animals after pollutant exposure were introduced.As a potential detoxifying and therapeutic agent,baicalein has strong detoxification effects with few side effects.Baicalein has important potential value and broad application prospects in repairing organ damage or chronic diseases caused by environmental pollutants.

关 键 词：环境污染物 黄芩素 解毒 药理 

分 类 号：R285[医药卫生—中药学] X173[医药卫生—中医学]