两种国产口腔生物膜在糖尿病患者单牙种植引导性骨组织再生中的骨增量效果初探  

Exploring the clinical application effects of two different sources of domestic oral restoration membrane in guided bone regeneration during dental implantation in diabetic patients

作　　者：李婧 董岩 王富 许克惠 王晨语 陈莉 牛丽娜 Li Jing;Dong Yan;Wang Fu;Xu Kehui;Wang Chenyu;Chen Li;Niu Lina(Department of Prosthodontics,School of Stomatology,The Fourth Military Medical University,State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Stomatology,Xi′an 710032,China)

机构地区：[1]第四军医大学口腔医院口腔修复科,口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔医学重点实验室,西安710032

出　　处：《中华口腔医学杂志》2025年第2期116-122,共7页Chinese Journal of Stomatology

基　　金：中华口腔医学会青年临床科研基金(CSA-SIS2022-15);空军军医大学科技创新人才助推“领航行动”项目“新飞计划”(4457475042JZ2300SR)。

摘　　要：目的探讨两种国产口腔生物膜[脱细胞猪小肠黏膜下层可吸收生物膜(PSIS)与牛心包组织可吸收生物膜(BPT)]于糖尿病患者单牙种植引导性骨组织再生(GBR)中的骨增量效果。方法选取2023年1月至2024年1月于第四军医大学口腔医院口腔修复科行单牙种植修复的48例糖尿病患者, 进行前瞻性病例对照研究。采用随机数字表法将患者分为研究组(PSIS组)和对照组(BPT组), 每组各24例, 种植手术同期行相应材料GBR。通过锥形束CT比较两组患者术后6个月颊侧水平骨增量效果, 结合创面愈合评分分析术后1、4周伤口愈合情况。结果术后6个月, 研究组种植体基台下2 mm处颊侧水平骨增量效果[69.1(55.2, 82.4)mm]与对照组[71.4(59.8, 77.0)mm]差异无统计学意义(Z=-0.25, P=0.805);研究组术后1、4周创面愈合评分与相同时间点对照组差异均无统计学意义(Z=-0.49, P=0.627;Z=-0.61, P=0.539)。结论两种来源的国产口腔生物膜用于糖尿病患者单牙种植GBR, 两组术后6个月颊侧水平骨增量效果以及术后1、4周伤口愈合的临床效果相当, PSIS与BPT的GBR效果相似。ObjectiveTo investigate the bone augmentation effects of domestic decellularized porcine small intestinal submucosa(PSIS)absorbable biomembrane and domestic bovine pericardium tissue(BPT)absorbable biomembrane in guided bone regeneration(GBR)for single-tooth implantation in diabetic patients.MethodsA prospective case-control study was conducted with 48 diabetic patients who received single-tooth implant restoration at the Department of Prosthodontics,School of Stomatology.The Fourth Military Medical University,between January 2023 and January 2024.Patients were randomly assigned to the study group(PSIS group)and the control group(BPT group)using a random number table,with 24 patients in each group.GBR was performed simultaneously with the implant surgery.Cone-beam CT was used to compare the buccal-side horizontal bone gain at 6 months post-operation between the two groups.Wound healing was evaluated at 1 and 4 weeks post-operation using wound healing scores.ResultsAt 6 months post-operation,the buccal-side horizontal bone gain at 2 mm below the implant abutment in the study group[69.1(55.2,82.4)mm]and the control group[71.4(59.8,77.0)mm]showed no statistically significant difference(Z=-0.25,P=0.805).The wound healing scores at 1 and 4 weeks post-operation in the study group did not differ significantly from those in the control group at the same time points(1 week:Z=-0.49,P=0.627;4 weeks:Z=-0.61,P=0.539).ConclusionsThe use of two types of domestic absorbable collagen membranes for GBR in single-tooth implantation in diabetic patients showed comparable buccal-side horizontal bone gain effects at 6 months post-operation and similar clinical outcomes for wound healing at 1 and 4 weeks post-operation in both groups.The GBR effects of PSIS and BPT are similar.

关 键 词：牙种植 糖尿病 胶原膜 引导性骨组织再生 

分 类 号：R587.1[医药卫生—内分泌] R783.6[医药卫生—内科学]