甲状腺过氧化物酶自身抗体在寻常型天疱疮与桥本甲状腺炎共病中的作用研究  

Role of thyroid peroxidase autoantibody in the comorbidities of pemphigus vulgaris and Hashimoto thyroiditis

作　　者：陈丽好 张丽娟[2] 张艳昕 石晶 Chen Lihao;Zhang Lijuan;Zhang Yanxin;Shi Jing(Department of Oral Medicine,Shanxi Medical University School and Hospital of Stomatology,Taiyuan 030001,China;Department of Oral Medicine,Fifth Hospital of Shanxi Medical University&Shanxi Oral Health Prevention and Control Technology Innovation Center,Taiyuan 030012,China)

机构地区：[1]山西医科大学口腔医学院·口腔医院口腔内科,太原030001 [2]山西医科大学第五医院口腔内科,山西省口腔健康防控技术创新中心,太原030012

出　　处：《中华口腔医学杂志》2025年第2期179-183,共5页Chinese Journal of Stomatology

基　　金：山西省医学科技创新团队建设项目(2020TD17)。

摘　　要：寻常型天疱疮(PV)是一组可能危及生命的以上皮内水疱为特征的自身免疫大疱性疾病, 临床上以黏膜主导型多见。桥本甲状腺炎(HT)是一类甲状腺特异性抗体异常增多导致甲状腺功能减退的自身免疫性疾病, 甲状腺过氧化物酶自身抗体(TPOAb)为其特异性抗体。近年来, PV患者伴发HT的概率呈上升趋势, 二者共病可能与TPOAb作用于口腔角质形成细胞有关。本文就PV与HT的流行病学关系以及TPOAb在二者共病中的作用机制作一综述, 以期为PV与HT的临床诊疗提供思路。Pemphigus vulgaris(PV)is a group of autoimmune bullous diseases characterized by life-threatening intradermal blisters.Hashimoto thyroiditis(HT)is a kind of autoimmune disease with abnormal increase of thyroid peroxidase autoantibody(TPOAb),which is the thyroid specific antibody,leading to hypothyroidism.In recent years,the probability of HT in patients with PV is increasing,and the co-disease may be related to the effect of TPOAb autoantibody on oral keratinocytes.This article reviews the epidemiological relationship between PV and HT and the mechanism of TPOAb in their co-disease,in order to provide ideas for the diagnosis and treatment of both.

关 键 词：天疱疮 甲状腺炎 寻常型天疱疮 桥本甲状腺炎 桥粒芯糖蛋白质类 甲状腺过氧化物酶自身抗体 

分 类 号：R581.4[医药卫生—内分泌] R758.66[医药卫生—内科学]