肺炎支原体肺炎患儿肺功能指标及外周血嗜酸性粒细胞水平分析  

Analysis on pulmonary function indexes and peripheral blood eosinophil level in children with Mycoplasma pneumoniae pneumonia

作　　者：陆美荣 伍倩 刘汉琼 莫长凤 LU Mei-rong;WU Qian;LIU Han-qiong;MO Chang-feng(Department of Pediatrics,the Fifth Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530022,China)

机构地区：[1]广西医科大学第五附属医院儿科,广西南宁530022

出　　处：《中国妇幼保健》2025年第4期642-645,共4页Maternal and Child Health Care of China

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20221083)。

摘　　要：目的分析肺炎支原体肺炎(MPP)患儿肺功能指标及外周血嗜酸性粒细胞水平,为临床诊治提供参考。方法选取2022年在广西医科大学第五附属医院儿科住院的100例肺炎患儿,分为MPP组(55例)和非MPP组(45例),MPP组根据肺炎支原体抗体(MP-Ab)滴度分为高滴度组(24例)和低滴度组(31例)。比较不同组间患儿肺功能指标及外周血嗜酸性粒细胞水平。结果MPP组患儿用力肺活量(FVC)、第1秒用力呼气量(FEV_(1))、FEV_(1)/FVC、最大呼气流量(PEF)、用力呼出25%肺活量时的瞬间流量(FEF25)、用力呼出50%肺活量时的瞬间流量(FEF50)、用力呼出75%肺活量时的瞬间流量(FEF75)、最大呼气中期流量(MMEF)分别为(1.74±0.50)L、(1.48±0.38)L、(85.68±7.35)%、(3.07±0.83)L/s、(2.71±0.69)L/s、(1.77±0.50)L/s、(0.80±0.25)L/s、(1.49±0.41)L/s,非MPP组患儿上述各项指标分别为(1.88±0.59)L、(1.70±0.57)L、(90.10±4.50)%、(3.50±1.52)L/s、(3.29±1.04)L/s、(2.35±0.81)L/s、(1.13±0.55)L/s、(2.02±0.76)L/s,MPP组患儿FEV_(1)/FVC、FEV_(1)、PEF、FEF25、FEF50、FEF75、MMEF均低于非MPP组,差异均有统计学意义(均P<0.05)。低滴度组和高滴度组患儿肺功能指标比较,差异均无统计学意义(均P>0.05)。MPP组患儿外周血白细胞计数、中性粒细胞计数、中性粒细胞百分比(NEUT%)、嗜酸性粒细胞计数、嗜酸性粒细胞百分比(EOS%)、C-反应蛋白(CRP)、总免疫球蛋白E(tIgE)、呼出气一氧化氮(FeNO)水平分别为(7.95±3.02)×10^(9)/L、(5.21±3.24)×10^(9)/L、(0.62±0.59)%、(0.48±0.38)×10^(9)/L、(0.05±0.04)%、(6.35±11.50)mg/L、(398.48±398.47)g/L、(17.40±18.34)ppb,非MPP组患儿外周血白细胞计数、中性粒细胞计数、NEUT%、嗜酸性粒细胞计数、EOS%、CRP、tIgE、FeNO水平分别为(8.95±3.41)×10^(9)/L、(5.57±3.40)×10^(9)/L、(0.56±0.16)%、(0.20±0.16)×10^(9)/L、(0.02±0.01)%、(7.21±16.29)mg/L、(321.10±371.28)g/L、(11.20±6.41)ppb,MPP组患儿EOS%、嗜酸性粒细胞计Objective To analyze pulmonary function indexes and peripheral blood eosinophil level in children with Mycoplasma pneumoniae pneumonia(MPP),and provide reference for clinical diagnosis and treatment.Methods A total of 100 children with MPP who hospitalized in Department of Pediatrics in the Fifth Affiliated Hospital of Guangxi Medical University in 2022 were selected and divided into MPP group(55 cases)and non-MPP group(45 cases).According to different titers of Mycoplasma pneumoniae antibody(MP-Ab),the children in MPP group were divided into high titer group(24 cases)and low titer group(31 cases).The pulmonary function indexes and peripheral blood eosinophil levels were compared between different groups.Results The levels of forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1)),FEV_(1)/FVC,peak expiratory flow(PEF),instantaneous flow when exhaling 25%of lung capacity forcefully(FEF25),instantaneous flow when exhaling 50%of lung capacity forcefully(FEF50),instantaneous flow when exhaling 75%of lung capacity forcefully(FEF75),and maximum mid-expiratory flow(MMEF)in MPP group were(1.74±0.50)L,(1.48±0.38)L,(85.68±7.35)%,(3.07±0.83)L/s,(2.71±0.69)L/s,(1.77±0.50)L/s,(0.80±0.25)L/s,and(1.49±0.41)L/s,respectively,the above-mentioned indexes in non-MPP group were(1.88±0.59)L,(1.70±0.57)L,(90.10±4.50)%,(3.50±1.52)L/s,(3.29±1.04)L/s,(2.35±0.81)L/s,(1.13±0.55)L/s,and(2.02±0.76)L/s,respectively,FEV_(1)/FVC,FEV_(1),PEF,MEF25,MEF50,MEF75,and MMEF in MPP group were statistically significantly lower than those in non-MPP group(all P<0.05).There was no statistically significant difference in pulmonary function indexes between high titer group and low titer group(all P>0.05).The levels of peripheral blood white blood cell count,neutrophil count,neutrophil percentage(NEUT%),eosinophil count,eosinophil percentage(EOS%),C-reactive protein(CRP),total immunoglobulin E(tIgE),and fractional exhaled nitric oxide(FeNO)in MPP group were(7.95±3.02)×10^(9)/L,(5.21±3.24)×10^(9)/L,(0.62±0.59)%,(0.

关 键 词：儿童 肺炎支原体肺炎 肺功能 嗜酸性粒细胞 

分 类 号：R725.6[医药卫生—儿科]