新鲜周期卵裂期胚胎移植后补充雌激素对体外受精-胚胎移植临床结局的影响  

Impact of estrogen supplementation on the clinical outcome of IVF-ET fresh cycles after cleavage-stage embryo transfer

作　　者：韩颖 张丽欣 李秦宇琦 薄文 吴凤艳 HAN Ying;ZHANG Li-xin;LI Qin-yu-qi;BO wen;WU Feng-yan(Department of Reproductive Medicine,Affiliated Hospital of Chifeng University,Chifeng,Inner Mongolia 024000,China)

机构地区：[1]赤峰学院附属医院生殖医学科,内蒙古赤峰024000

出　　处：《中国妇幼保健》2025年第4期672-675,共4页Maternal and Child Health Care of China

基　　金：内蒙古自治区赤峰市自然科学科研课题(SZR2022150);赤峰学院青年科研基金项目(CFXYQNZR2205)。

摘　　要：目的探讨GnRH-a长方案和GnRH-ant方案新鲜周期卵裂期胚胎移植后补充雌激素对体外受精-胚胎移植(IVFET)临床结局的影响。方法采用前瞻性随机对照研究,选择2022年4月—2022年9月于赤峰学院附属医院生殖医学科进行GnRH-a长方案和GnRH-ant方案新鲜周期卵裂期胚胎移植的患者120例为研究对象,分为观察组和对照组,观察组于胚胎移植术后第3天补充雌激素,剂量为4 mg/d,对照组不补充雌激素,对比两组的生化妊娠率和临床妊娠率。结果GnRH-a长方案观察组的生化妊娠率高于对照组(75.6%vs.67.5%),且临床妊娠率也高于对照组(65.9%vs.57.5%),但是差异均无统计学意义(均P>0.05)。GnRH-ant方案观察组的生化妊娠率低于对照组(71.4%vs.76.9%),而临床妊娠率高于对照组(64.3%vs.61.5%),但差异均无统计学意义(均P>0.05)。结论GnRH-a长方案和GnRH-ant方案新鲜周期卵裂期胚胎移植后术后补充雌激素可能提高IVF-ET临床妊娠率,但无显著性差异。Objective To explore the impact of supplementing estrogen after fresh cycle cleavage-stage embryo transfer in GnRH agonist(GnRH-a)long protocol and GnRH antagonist(GnRH-ant)on the clinical outcome of in vitro fertilization-embryo transfer(IVFET).Methods A prospective randomized controlled study was conducted.A total of 120 patients who underwent fresh cycle cleavage-stage embryo transfer in GnRH-a long protocol and GnRH-ant protocol in the Reproductive Medicine Department of Affiliated Hospital of Chifeng University from April 2022 to September 2022 were selected as the research objects and divided into an observation group and a control group.The observation group received a 4 mg/d dose of estrogen supplementation on the third day following embryo transfer,whereas the control group did not receive any estrogen supplementation.The biochemical pregnancy rate and clinical pregnancy rate of the two groups were compared.Results In the GnRH-a long protocol,the observation group had a higher biochemical pregnancy rate compared with the control group(75.6%vs.67.5%),and a higher rate of clinical pregnancy compared with the control group(65.9%vs.57.5%),but none of the differences were statistically significant(P>0.05).The biochemical pregnancy rate of the observation group in the GnRH-ant protocol was lower than that of the control group(71.4%vs.76.9%),while the clinical pregnancy rate was higher than that of the control group(64.3%vs.61.5%),but the differences were not statistically significant(P>0.05).Conclusion The addition of estrogen supplementation following fresh cycle cleavage embryo transfer between GnRH-a long protocol and GnRH-ant protocol may enhance the clinical pregnancy rate of IVF-ET,although no significant difference was observed.

关 键 词：体外受精 胚胎移植 新鲜周期 雌激素 妊娠率 

分 类 号：R711[医药卫生—妇产科学]