皮肤力医学  

Skin mechanomedicine

作　　者：耿松梅[1,2] 胡佳辉 赵强 冯雨晴[1,2] 王熙 刘灏 徐峰[3,4] Geng Songmei;Hu Jiahui;Zhao Qiang;Feng Yuqing;Wang Xi;Liu Hao;Xu Feng(Department of Dermatology,Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710004,China;Center for Dermatology Disease,Precision Medical Institute,Xi′an 710115,China;Bioinspired Engineering and Biomechanics Center(BEBC),School of Life Science and Technology,Xi′an Jiaotong University,Xi′an 710049,China;Ministry of Education Key Laboratory of Biomedical Information Engineering,School of Life Science and Technology,Xi′an Jiaotong University,Xi′an 710049,China)

机构地区：[1]西安交通大学第二附属医院皮肤科,西安710004 [2]西安交通大学精准医学研究院皮肤病研究所,西安710115 [3]西安交通大学生命科学与技术学院仿生工程与生物力学研究所(BEBC),西安710049 [4]西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室,西安710049

出　　处：《中华医学杂志》2025年第7期489-496,共8页National Medical Journal of China

基　　金：国家自然科学基金(12225208、12302424);陕西省创新团队(2022TD‑48);陕西省重点产业创新链(2024SF‑ZDCY L‑01‑14);陕西省科协青年人才托举计划(20220302);中央高校基本科研业务费专项基金(xtr062023002)。

摘　　要：长期以来,皮肤疾病的传统研究主要集中在其生物学特性上。近年来,生物力学和力学生物学两个交叉学科的发展逐渐将力学因素引入皮肤疾病的研究范畴,力学因素改变与皮肤生理病理变化的相互作用规律逐渐在临床疾病诊疗中得以转化,并产生了力诊断学和力治疗学两个立足于解决临床需求的新兴应用学科。然而,临床医师对于皮肤的力学特征以及皮肤病力学生物学机制的了解不够深入。因此,本文提出“皮肤力医学”这一概念。通过对国内外相关研究的总结,从皮肤生物力学、皮肤力生物学、皮肤力诊断学和皮肤力治疗学4个方面系统阐述皮肤疾病的多尺度力学特征及其对疾病生物学行为的影响,同时也对力学因素在皮肤疾病诊疗中的潜在应用进行了深入探讨,旨在为皮肤疾病诊疗提供新的研究视角和解决方案。Traditional research on skin diseases has mainly focused on biological characteristics for a long time.Recently,the integration of biomechanics and mechanobiology has introduced mechanical factors into skin disease research.The interaction between mechanical factors and skin′s physiological and pathological changes has gradually been transformed in clinical diagnosis and treatment.The two emerging fields,mechanodiagnostics and mechanotherapy,have been developed to address clinical needs.However,clinicians often lack a comprehensive understanding of skin mechanical characteristics and the mechanobiological mechanisms in dermatology.Thus,we propose the concept of"skin mechanomedicine".By summarizing relevant research at home and abroad,this paper systematically elucidates the multiscale mechanical characteristics of skin diseases and their impact on biological behavior from four perspectives:skin biomechanics,skin mechanobiology,skin mechanodiagnostics,and skin mechanotherapy.Meanwhile,in‑depth exploration was conducted on the potential application of mechanical factors in the diagnosis and treatment of skin diseases,aiming to provide new research perspectives and solutions for the diagnosis and treatment of skin diseases.

关 键 词：皮肤 皮肤生物力学 皮肤力生物学 皮肤力诊断学 皮肤力治疗学 

分 类 号：R751[医药卫生—皮肤病学与性病学] R318.01[医药卫生—临床医学]