2020—2022年全国血吸虫病监测点流动人群血清流行病学特征分析  

Serological epidemic characteristics of transient population at national schistosomiasis surveillance sites of China, 2020-2022

作　　者：郭苏影 李银龙 李仕祯 党辉 曹淳力 许静 李石柱[1,2] GUO Suying;LI Yinlong;LI Shizhen;DANG Hui;CAO Chunli;XU Jing;LI Shizhu(National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention,Chinese Center for Tropical Diseases Research,National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Key Laboratory on Parasite and Vector Biology,Ministry of Health,WHO Centre for Tropical Diseases,National Center for International Research on Tropical Diseases,Ministry of Science and Technology,Shanghai 200025,China;School of Global Health,Chinese Center for Tropical Diseases Research,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心),传染病溯源预警与智能决策全国重点实验室,国家卫生健康委员会寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,科技部国家级热带病国际研究中心,上海200025 [2]上海交通大学医学院-国家热带病研究中心全球健康学院,上海200025

出　　处：《中国寄生虫学与寄生虫病杂志》2024年第6期694-700,共7页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：上海市卫生健康委员会卫生行业临床研究专项(20214Y0212);国家自然科学基金(82073619)。

摘　　要：目的 分析2020—2022年全国血吸虫病监测点流动人群的血清流行病学特征和血清抗血吸虫抗体阳性者的流向构成,为制定流动人群血吸虫病监测方案提供科学依据。方法 收集中国传染病预防控制信息系统、寄生虫病防治信息管理系统中2020—2022年全国血吸虫病流动人群监测数据和流动人群血吸虫病病例个案流行病学调查数据,包括性别、年龄、职业和户籍地所在县等人口社会学特征信息、迁出地或迁入地等人口流动信息以及血吸虫病血清学和病原学检测结果。采用描述性流行病学分析流动人口的血清抗体水平的三间分布特征,采用卡方检验分析不同性别、年龄、职业组之间血清抗体阳性率的差异,采用χ^(2)分割法进行多组阳性率的两两比较,使用桑基图描述血清抗体阳性者的流向。结果 2020—2022年,13个省(自治区、直辖市) 455个监测县共检测6岁及以上流动人群302 460人次,1 199人次血清抗体检测结果为阳性,1人粪检结果为阳性。2020—2022年流动人群血清抗体阳性率依次为0.47%(450/96 596)、0.44%(442/101 558)、0.29%(307/104 306),2020与2021年均高于2022年(χ^(2)=39.310、28.178,均P <0.01)。2020—2022年,江西的血清抗体阳性率均为最高,分别为1.24%(91/7 316)、 1.33%(112/8 412)和0.65%(56/8 648);男性和女性血清抗体阳性率分别为0.48%(277/57 550)、 0.44%(173/39 046), 0.44%(260/59 458)、 0.43%(182/42 100), 0.31%(191/62 237)、 0.28%(116/42 069),各年度不同性别间差异均无统计学意义(χ^(2)=0.734、0.014、0.830,均P> 0.05);农民、渔船民、其他职业组血清抗体阳性率分别为0.82%(225/27 561)、0.86%(20/2 333)、0.31%(205/66 702),0.78%(226/28 928)、0.75%(16/2 141)、0.28%(200/70 489),0.53%(158/29 661)、0.91%(23/2 523)、0.17%(126/72 122),农民组与渔船民组的血清抗体阳性率均高于其他职业组(χ^(2)=111.287、118.991、96.799,20.985、15.060、66.450;均P <0.01)。2020—2022年6~1Objective To analyze the seroepidemiological characteristics in transient population and the moving direction of the individuals with positive serum anti-schistosome antibody at national schistosomiasis surveillance sites of China during 2020-2022,and to provide a scientific basis for formulating surveillance program for schistosomiasis in the transient population.Methods Data of the national population-based schistosomiasis surveillance and individual cases recorded from transient population during 2020-2022 were collected from the Information System for Infectious Diseases Prevention and Control and the Information System for Parasitic Disease Prevention and Control.The data include demographic characteristics of sex,age,occupation and the counties of residence registered,and the people migrating information regarding the locations of moving in or moving out from,as well as the results of serological and pathogenic examinations for schistosomiasis.Descriptive epidemiological methods were employed to analyze the spatial,temporal,and demographic distribution of the serum anti-schistosome level among the transient population.Chi-square analysis was used to compare the differences in the positive rates of serum antibodies among the groups of sex,age,and occupation.Partitions ofχ^(2) method was used for multiple comparisons of the positive rates.Sankey diagram was used to describe the moving direction of the individuals with positives serum antibodies.Results A total of 302460 person-time among the transient population was surveyed from 455 surveillance counties in 13 provinces(or autonomous regions or municipalities)in China from 2020 to 2022,and 1199 was found positive with serum antibodies,and one was positive with fecal examination.During 2020-2022,the positive rates of serum antibodies among the transient population were 0.47%(450/96596),0.44%(442/101558),and 0.29%(307/104306),respectively.The rates in 2020 and 2021 were both higher than the rate in 2022(χ^(2)=39.310,28.178;both P<0.01).During 2020-2022,the h

关 键 词：血吸虫病 监测 流动人群 流向 

分 类 号：R532.21[医药卫生—内科学]