巨噬细胞调控多房棘球蚴病所致肝纤维化研究进展  

Research progress of macrophage regulation of liver fibrosis induced by alveolar echinococcosis

作　　者：尹先敏 种世桂 陈根 秦俊梅 赵玉敏 YIN Xianmin;CHONG Shigui;CHEN Gen;QIN Junmei;ZHAO Yumin(Department of Parasitology,School of Basic Medical Sciences,Guilin Medical University,Guilin 541199,Guangxi,China;Gansu Medical Colledge,Pingliang 744099,Gansu,China)

机构地区：[1]桂林医学院基础医学院人体寄生虫学教研室,广西桂林541199 [2]甘肃医学院,甘肃平凉744099

出　　处：《中国寄生虫学与寄生虫病杂志》2024年第6期790-795,801,共7页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然基金地区项目(82460403);甘肃省高等学校产业支撑计划项目(2022CYZC-72)。

摘　　要：多房棘球蚴病(AE)是一种严重危害人类健康和畜牧业发展的人兽共患寄生虫病。AE病变周围各种免疫细胞(包括巨噬细胞)浸润增加,可造成以肝脏为主的多种重要器官纤维化,并可能发展成肝硬化和肝癌等严重疾病。几种巨噬细胞在AE肝脏炎症的进程以及纤维化形成的不同时期分别表现为M1型巨噬细胞或M2型巨噬细胞,并分泌促炎细胞因子和抗炎细胞因子,以此来促进早期棘球蚴的清除作用和中晚期的抗炎作用从而在AE肝脏纤维化的形成过程中发挥调控作用。本文从AE所致肝脏纤维化中几种巨噬细胞的调控机制作一论述。Alveolar echinococcosis(AE)is a zoonotic parasitic disease that poses a serious threat to human health and the development of animal husbandry.The augmented infiltration of various immune cells(including macrophages)around AE lesions can lead to fibrosis in various important organs,primarily the liver,and might progress into cirrhosis,liver cancer,and other serious disorders.Several types of macrophages manifest as M1 or M2 macrophages at different stages of AE liver inflammation and fibrosis formation,secreting pro-inflammatory and anti-inflammatory cytokines to promote the clearance of echinococcus in the early stage and exerting an anti-inflammatory effect in the middle and late stages,thereby playing a regulatory role in AE liver fibrosis formation.In this article,the regulatory mechanisms of several types of macrophages in AE-induced liver fibrosis are discussed.

关 键 词：多房棘球蚴病 巨噬细胞 肝脏纤维化 

分 类 号：R532.32[医药卫生—内科学]