中医药调节肠道微生态维持Th17/Treg平衡防治银屑病的机制  

The mechanism of traditional Chinese medicine regulating intestinal microbiota and maintaining Th17/Treg balance for the prevention and treatment of psoriasis

作　　者：张译丹 薛凯元 孙起超 高金金[2] 杨素清[2] 王和平[2] 袁锐[2] ZHANG Yidan;XUE Kaiyuan;SUN Qichao;GAO Jinjin;YANG Suqing;WANG Heping;YUAN Rui(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Afliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《生命的化学》2025年第1期25-34,共10页Chemistry of Life

基　　金：黑龙江省中医药科研项目(ZWY2024-057);2024年研究生创新科研项目(2024yjscx033)。

摘　　要：作为由T淋巴细胞(T lymphocyte)介导的免疫性皮肤疾病,银屑病(psoriasis,PsO)发病机制呈多因子多通路趋势,其病理表现为炎症细胞浸润和角质形成细胞的异常增殖。皮肤与肠道细胞结构均来源于同一胚胎层,具有相似的信号转导机制。现代医学将感染、微生态、免疫进行有机关联,二者的健康和稳态具有密切的联系。肠道菌群紊乱会引发相关炎症因子的大量释放,引发机体的免疫炎性反应,促进相关受体表达,进而导致辅助性T细胞17(Th17)/调节性T细胞(Treg)细胞平衡偏向Th17细胞,刺激角质形成细胞的增殖和分化,损害皮肤屏障完整性,加速PsO的发生与进展。中药对PsO的治疗有疗效持久、不良反应小且价格低廉等独特优势,但其作用机制尚不清晰。为此,本文从中药单体及复方调控肠道黏膜免疫的Th17/Treg平衡和肠道菌群紊乱出发,对防治PsO的文献进行系统性归纳、整理与分析,以期为中医药等相关领域防治PsO提供参考与思路。Psoriasis is an immune skin disease mediated by T lymphocytes.Its pathogenesis is a multi-factor and multi-pathway trend,and its pathology is characterized by inflammatory cell infiltration and abnormal proliferation of keratinocytes.The skin and intestinal cells both originate from the same embryonic layer and have similar signal transduction mechanisms.Modern medicine organically links infection,microecology,and immunity.The health and homeostasis of the two are closely related.Disorders of intestinal flora can cause a large amount of related inflammatory factors to be released,triggering immune inflammatory responses in the body,promoting the expression of related receptors,leading to a shift in the balance of T-helper 17(Th17)/regulatory T-cells(Treg)axis towards Th17 cells.This stimulates the proliferation and differentiation of keratinocytes,impairs the integrity of the skin barrier,and accelerates the occurrence and progression of PsO activation.Traditional Chinese medicine has unique advantages in the treatment of PsO,such as long-lasting efficacy,low side effects,and low cost.However,its mechanism is still unclear.Therefore,this paper systematically summarizes and analyzes the literature on the regulation of Th17/Treg inflammatory axis balance and intestinal flora disorders triggered by traditional Chinese medicine monomers and compounds to prevent and treat PsO.The aim is to provide a reference and ideas for the prevention and treatment of PsO in related fields of traditional Chinese medicine.

关 键 词：银屑病 肠道菌群 肠道免疫环境 Th17/Treg平衡 

分 类 号：R285[医药卫生—中药学]