178例高血压病患者收缩压昼夜节律与血压变异性及其左室射血分数的相关性探讨  

Discussion on the correlation between the systolic blood pressure circadian rhythm and blood pressure variability and the left ventricular blood ejection among 178 patients with hypertension

作　　者：张佳[1] 陆雪琴[1] 刘琳琳 张雯 李光召 庞家栋 刘永明[3] 鲁成[3] 金咏梅[1] Zhang Jia;Lu Xueqin;Liu Linlin;Zhang Wen;Li Guangzhao;Pang Jiadong;Liu Yongming;Lu Cheng;Jin Yongmei(Cardiovascular Department,Shanghai Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China;Cardiac Rehabilitation Department,the First Rehabilitation Hospital of Shanghai,Shanghai 200082,China;Cardiovascular Department,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属第七人民医院心内科,上海200137 [2]上海市第一康复医院心脏康复科,上海200082 [3]上海中医药大学附属曙光医院心内科,上海201203

出　　处：《国际中医中药杂志》2025年第1期23-28,共6页International Journal of Traditional Chinese Medicine

基　　金：上海市浦东新区卫生系统优秀青年医学人才培养计划(PWRq2020-34);国家自然科学基金(81973611);上海市青年科技英才扬帆计划(20YF1436800);浦东新区“中央财政支持中医药传承创新发展示范试点项目”(YC-2023-0119);上海中医药大学首届杏林学者护理青年(2022HLXL04);上海市第七人民医院临床研究项目(2023XG016)。

摘　　要：目的探讨178例高血压病患者收缩压(SBP)昼夜节律与血压变异性(BPV)及其左室射血分数(LVEF)的关系。方法多中心回顾性研究。按纳入标准选取2020年1月-2022年1月178例原发性高血压病患者作为观察对象,均行24 h动态血压监测及超声心动图检查。收集患者昼夜节律、BPV、心脏超声心动图等相关数据,探讨SBP昼夜节律与BPV及LVEF关系。结果178例患者中,昼夜节律降低患者>昼夜节律存在患者>昼夜节律倒置患者>昼夜节律消失患者;SBP昼夜节律消失患者年龄低于倒置患者[(63.8±14.5)岁比(71.5±9.4)岁,P<0.05];SBP昼夜节律存在患者24 h SBP标准差低于倒置患者[(13.1±2.8)mmHg比(15.2±3.1)mmHg,P<0.05];SBP昼夜节律存在患者LVEF高于倒置患者[(68.2±6.5)%比(62.9±9.6)%,P<0.05]。结论SBP昼夜节律倒置时BPV最大,LVEF最低。Objective To discuss the relationship between the systolic blood pressure(SBP)circadian rhythm and blood pressure variability(BPV)and the left ventricular ejection fraction(LVEF)among 178 patients with hypertension.Methods This article was a retrospective study.Totally 178 patients with hypertension from January 2020 to January 2022 were selected based on incorporated basis.24-hour dynamic blood pressure monitoring and echocardiography examination were performed.Data such as patients'SBP circadian rhythm,BPV,heart ultrasound heart dynamic maps were collected,and the relationship between SBP circadian rhythm and BPV and their LVEF was explored.Results Among the 178 patients,the decreased proportion of SBP circadian rhythm>the proportion of existed SBP circadian rhythm>the proportion of inverted SBP circadian rhythm>the proportion of disappearance of SBP circadian rhythm;patients with disappearance of SBP circadian rhythm were the youngest(63.8±14.5)years old,and patients with inverted SBP circadian rhythm were the oldest(71.5±9.4)years old(P<0.05);the 24-hour systolic blood pressure standard deviation of SBP circadian rhythm was observed in patients with(13.1±2.8)mmHg<inverted patients with(15.2±3.1)mmHg(P<0.05);patients'LVEF(68.2±6.5)%was the highest during the existence of SBP circadian rhythm,and patients'LVEF(62.9±9.6)%was the lowest at inverted systolic pressure circadian rhythm(P<0.05).Conclusion The blood pressure variability is the highest and the left ventricular ejection score is the lowest when the systolic pressure circadian rhythm is inverted.

关 键 词：高血压 昼夜节律 血压变异性 左室射血分数 

分 类 号：R54[医药卫生—心血管疾病]