喀什地区艾滋病合并结核病患者抗结核治疗依从性及其影响因素  

Compliance of patients with AIDS complicated tuberculosis in Kashgar area to anti tuberculosis treatment and its influencing factors

作　　者：吴超[1] 沙拉麦提·阿布力孜 WU Chao;SHALAMATI Abulizi(Department of Infection,Kashgar First People's Hospital,Kashgar 844000,China)

机构地区：[1]喀什地区第一人民医院感染科,新疆喀什844000

出　　处：《东南大学学报(医学版)》2025年第1期73-78,共6页Journal of Southeast University(Medical Science Edition)

基　　金：省部共建中亚高发病成因与防治国家重点实验室开放课题项目(SKL-HIDCA-2021-KS4)。

摘　　要：目的:调查喀什地区艾滋病合并结核病患者抗结核治疗依从性及影响因素。方法:2021年1月至2023年6月,选取本院收治的110例艾滋病合并结核病患者,根据其抗结核治疗依从性情况分为依从性差组和依从性好组,用Logistic回归分析筛选喀什地区艾滋病合并结核病患者抗结核治疗依从性的影响因素。结果:喀什地区110例艾滋病合并结核病患者中,59例(占53.64%)依从性好,51例(占46.36%)依从性差。文化程度“小学及以下”(OR=4.007,95%CI:2.107~7.621,P<0.001)、文化程度“初中”(OR=2.159,95%CI:1.392~3.349,P=0.001)、文化程度“高中及中专”(OR=1.458,95%CI:1.039~2.047,P=0.029)、经济状况较差(OR=3.738,95%CI:1.453~9.614,P=0.006)、吸烟(OR=4.001,95%CI:1.481~10.808,P=0.006)、饮酒(OR=2.201,95%CI:1.133~4.277,P=0.020)、有药物不良反应(OR=5.117,95%CI:2.216~11.816,P<0.001)、结核病核心知识知晓情况<4分(OR=6.123,95%CI:3.238~11.577,P<0.001)是喀什地区艾滋病合并结核病患者抗结核治疗依从性差的独立危险因素。结论:喀什地区艾滋病合并结核病患者抗结核治疗依从性有待提升,可针对文化程度、经济状况、吸烟、饮酒、药物不良反应、结核病核心知识知晓情况等影响因素展开个体化干预。Objective:To investigate the compliance of patients with AIDS complicated tuberculosis in Kashgar area to anti tuberculosis treatment and its influencing factors.Methods:A total of 110 patients with AIDS complicated with tuberculosis admitted to our hospital from January 2021 to June 2023 were divided into poor compliance group and good compliance group according to their compliance to anti tuberculosis treatment.Logistic regression analysis was applied to screen the influencing factors of compliance of patients with AIDS complicated tuberculosis in Kashgar area to anti tuberculosis treatment.Results:Among 110 patients with AIDS complicated tuberculosis in Kashgar area,59 cases(53.64%)had good compliance and 51 cases(46.36%)had poor compliance.Education level of“primary school and below”(OR=4.007,95%CI:2.107-7.621,P<0.001),education level of“junior high school”(OR=2.159,95%CI:1.392-3.349,P=0.001),education level of“high school and technical secondary school”(OR=1.458,95%CI:1.039-2.047,P=0.029),poor economic status(OR=3.738,95%CI:1.453-9.614,P=0.006),smoking(OR=4.001,95%CI:1.481-10.808,P=0.006),drinking alcohol(OR=2.201,95%CI:1.133-4.277,P=0.020),adverse drug reactions(OR=5.117,95%CI:2.216-11.816,P<0.001),awareness of tuberculosis core knowledge<4 points(OR=6.123,95%CI:3.238-11.577,P<0.001)were independent risk factors for poor compliance of patients with AIDS complicated tuberculosis in Kashgar area to anti tuberculosis treatment.Conclusion:The compliance of patients with AIDS complicated tuberculosis in Kashgar area to anti tuberculosis treatment needs to be improved.Individualized intervention can be carried out according to the influencing factors such as educational level,economic status,smoking,alcohol consumption,adverse drug reactions,and awareness of tuberculosis core knowledge.

关 键 词：喀什地区 艾滋病合并结核病 抗结核治疗 依从性 影响因素 

分 类 号：R512.91[医药卫生—内科学] R52[医药卫生—临床医学] R184.6