消瘿合剂对甲状腺消融区体积缩小率影响  

Effect of Xiaoying Mixture(消瘿合剂)on the Volume Reduction Rate of Thyroid Ablation Area

作　　者：赵璐璐 周绍荣[1] 盛建国 韩秋成[1] 郭佳 李卓[1] 卢峰 ZHAO Lulu;ZHOU Shaorong;SHENG Jianguo;HAN Qiucheng;GUO Jia;LI Zhuo;LU Feng(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

机构地区：[1]上海中医药大学附属曙光医院,上海200021

出　　处：《辽宁中医药大学学报》2025年第3期150-154,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：上海市临床重点专科项目(外科)(LH.02.91.002);上海市卫生健康委员会中医药科研青年项目(2024QN001)。

摘　　要：目的探讨消瘿合剂对甲状腺消融区体积缩小率(volume reduction ratio,VRR)的影响。方法回顾性分析于2021年6月—2023年3月就诊于上海中医药大学附属曙光医院的228例经微波消融治疗的单发甲状腺结节患者,其中联合治疗组98例患者在消融治疗后服用了3个月的消瘿合剂(首诊于中医外科),对照组130例患者只进行了消融治疗(首诊于超声医学科)。比较术后即刻、术后1个月、术后3个月、术后6个月的消融区体积大小。结果(1)两组患者消融后即刻消融区体积大于治疗前结节的体积,术后1个月、3个月、6个月的消融区体积逐渐缩小,差异有统计学意义。(2)联合治疗组与对照组的消融后即刻消融区体积比较,差异无统计学意义。联合治疗组在术后1、3、6个月的消融区VRR均大于对照组,差异有统计学意义。(3)同一组各个随访时间节点,甲状腺乳头状微小癌(papillary thyroid microcarcinoma,PTMC)与≤10 mm良性结节的消融区VRR比较,差异没有统计学意义。结论甲状腺结节微波消融治疗安全、有效,消瘿合剂可以促进甲状腺消融区的吸收。两者联合应用标本兼治,疗效显著,值得进一步研究推广。Objective To explore the effect of Xiaoying Mixture(消瘿合剂)on the volume reduction rate(VRR)of thyroid ablation area.Methods A retrospective analysis was performed on 228 patients with solitary thyroid nodules who were treated with microwave ablation in Shuguang hospital affiliated to Shanghai university of traditional Chinese medicine from June 2021 to March 2023.Among them,combined treatment group 98 patients took Xiaoying Mixture for 3 months after ablation treatment(first visit to the department of traditional Chinese medicine surgery),and control group 130 patients only underwent ablation treatment(first visit to the department of ultrasound medicine).The volume of the ablation zone was compared immediately after surgery,1 month after surgery,3 months after surgery,and 6 months after surgery.Results(1)The volume of the ablation zone immediately in the two groups after ablation were larger than the volume of the nodule before treatment,and the volume of the ablation zone gradually decreased 1 month,3 months,and 6 months after surgery,and the difference was statistically significant.(2)There was no statistically significant difference in the volume of the ablation zone immediately after ablation between the combined treatment group and the control group.The VRR of the ablation zone in the combined treatment group was greater than that in the control group at 1 month,3 months,and 6 months after surgery,and the difference was statistically significant.(3)In the same group,at each follow-up time point,there was no statistically significant difference in the VRR of the ablation zone between papillary thyroid microcarcinoma(PTMT)and benign nodules≤10 mm.Conclusion Microwave ablation of thyroid nodules is safe and effective,and Xiaoying Mixture can promote the absorption of the thyroid ablation zone.The combined use of the two can treat both the symptoms and the root cause,with significant efficacy,and is worthy of further research and promotion.

关 键 词：微波消融 消瘿合剂 体积缩小率 甲状腺乳头状微小癌 良性甲状腺结节 

分 类 号：R289.5[医药卫生—方剂学]