心房颤动患者血清galectin-3和MCP-1、CXCL12水平表达与心房纤维化程度及射频消融术后复发的相关性研究  

Correlation between serum galectin-3,MCP-1 and CXCL12 levels and the degree of atrial fibrosis and recurrence after radiofrequency ablation in patients with atrial fibrillation

作　　者：张景迪 穆清[1] ZHANG Jingdi;MU Qing(The First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan 473000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院,河南南阳473000

出　　处：《中国医学工程》2025年第2期69-73,共5页China Medical Engineering

摘　　要：目的 探究心房颤动患者血清半乳糖凝集素-3 (galectin-3)和单核细胞趋化蛋白1 (MCP-1)、趋化因子基质细胞衍生因子-1 (CXCL12)水平表达与心房纤维化程度及射频消融术后复发的相关性。方法 以2022年1月至2023年11月收治的90例心房颤动患者为研究对象,所有患者均接受射频消融术治疗,经1年随访,根据术后复发情况将患者分为复发组(复发25例)和未复发组(未复发65例)。检测并比较两组患者血清galectin-3和MCP-1、CXCL12水平、心房纤维化程度及心房纤维化指标,血清galectin-3和MCP-1、CXCL12水平三者在心房颤动的相关性分析,血清galectin-3和MCP-1、CXCL12水平与心房纤维化程度及射频消融术后复发的相关性分析。结果 两组患者基本资料及红细胞(RBC)、白细胞(WBC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血肌酐(Scr)水平比较,差异无统计学意义(P>0.05);左室收缩末期内径(LVDs)、左心室舒张末期内径(LVDd)水平比较,差异有统计学意义(P<0.05);治疗后,未复发组galectin-3、MCP-1、CXCL12水平均低于复发组(P<0.05);与未复发组相比,复发组心房纤维化重度较多,Ⅰ型前胶原羧基端原肽(PⅠCP)、Ⅲ型前胶原羧基端原肽(PⅢCP)、MMP-1指标水平较低(P<0.05);galectin-3、MCP-1、CXCL12三者水平在心房颤动患者中呈现出正相关;galectin-3、MCP-1、CXCL12与心房纤维化程度及射频消融术后复发均呈现正相关。结论 血清galectin-3和MCP-1、CXCL12水平与心房纤维化程度及射频消融术后复发存在一定的相关性,galectin-3、MCP-1、CXCL12在心房颤动患者中呈现正相关,能有效地为临床对患者病情的判断提供有力依据,可通过其水平变化评估患者术后复发风险。【Objective】 To explore the correlation between the expression of serum galectin-3,monocyte chemoattractant protein-1(MCP-1),and chemokine stromal cell-derived factor-1(CXCL12) levels and the degree of atrial fibrosis and recurrence after radiofrequency ablation in patients with atrial fibrillation.【Methods】 In this study,90 patients with atrial fibrillation admitted from January 2022 to November 2023 were studied.All patients received radiofrequency ablation.After 1-year follow-up,the patients were divided into 25 patients with recurrence(relapse group) and 65 patients without recurrence(non-recurrence group)according to postoperative recurrence.Serum galectin-3,MCP-1,CXCL12 levels,degree of atrial fibrosis and indexes of atrial fibrosis were detected and compared between the two groups,the relationship among serum galectin-3,MCP-1 and CXCL12 levels in patients with atrial fibrillation was analyzed,and the correlation between serum galectin-3,MCP-1,CXCL12 levels and atrial fibrosis degree,recurrence after radiofrequency ablation was analyzed.【Results】 There were no statistically significant differences in basic information and levels of RBC,WBC,HDL,LDL,and Scr between the two groups(P>0.05).LVDs and LVDd levels were significantly different between the two groups(P<0.05).After treatment,the levels of galectin-3,MCP-1,and CXCL12 in the nonrecurrent group were lower than those in the recurrent group(P<0.05).Compared with the non-recurrent group,the recurrent group had more severe atrial fibrosis and lower levels of PⅠCP,PⅢCP,and MMP-1 indicators(P<0.05).The levels of galectin-3,MCP-1,and CXCL12 showed positive correlations in patients with atrial fibrillation.There were positive correlations between galectin-3,MCP-1,CXCL12 and the degree of atrial fibrosis and recurrence after radiofrequency ablation.【Conclusion】 Serum galectin-3,MCP-1 and CXCL12 levels are correlated with the degree of atrial fibrosis and the recurrence after radiofrequency ablation.Galectin-3,MCP-1 and CXCL12 are positively cor

关 键 词：心房颤动 血清半乳糖凝集素-3 单核细胞趋化蛋白1 趋化因子基质细胞衍生因子-1(CXCL12) 心房纤维化 射频消融术 

分 类 号：R541.75[医药卫生—心血管疾病]