纤维支气管镜肺泡灌洗联合阿奇霉素治疗难治性支原体肺炎患儿的临床效果  

Clinical Effect of Fiberoptic Bronchoscopy-Alveolar Lavage Combined with Azithromycin in the Treatment of Children with Refractory Mycoplasma Pneumonia

作　　者：黄佳林 帅维[1] 黄玮 HUANG Jialin;SHUAI Wei;HUANG Wei(Department of Pediatrics,Huangmei County People's Hospital(General Hospital of Huangmei County Medical Community),Huanggang 436500,China;Department of Internal Medicine and Pediatrics,Hefei Aikang Health Examination Center,Hefei 230031,China)

机构地区：[1]黄梅县人民医院(黄梅县医共体总医院)儿科,湖北黄冈436500 [2]合肥爱康健康体检中心内儿科,安徽合肥230031

出　　处：《反射疗法与康复医学》2024年第24期88-91,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨纤维支气管镜肺泡灌洗联合阿奇霉素(AZM)治疗小儿难治性支原体肺炎(RMPP)的临床效果。方法选取2022年6月—2024年6月黄梅县人民医院收治的120例RMPP患儿为研究对象,按随机数字表法将其分为对照组和观察组,每组60例。两组患儿均行常规治疗后,对照组采用AZM治疗,观察组在对照组的基础上联用纤维支气管镜肺泡灌洗治疗,两组患儿均持续治疗12 d。对比两组的临床疗效、炎症指标、肺功能、症状改善时间、不良反应发生情况。结果观察组治疗总有效率为93.33%,高于对照组的76.67%,差异有统计学意义(P<0.05)。治疗后,观察组白细胞介素-6、γ-干扰素、肿瘤坏死因子-α水平均低于对照组,第1秒用力呼气容积、用力肺活量均大于对照组,最高呼气峰流速快于对照组,组间差异有统计学意义(P<0.05)。观察组发热、咳嗽、肺部湿啰音改善时间均短于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论纤维支气管镜肺泡灌洗联合AZM可减轻RMPP患儿炎症反应,可加快肺功能恢复,缩短不适症状改善时间,提高疗效,且用药安全。Objective To investigate the clinical effect of bronchoscopic-alveolar lavage combined with AZithromycin(AZM)in the treatment of children with refractory mycoplasma pneumonia(RMPP).Methods One hundred and twenty children with RMPP admitted to Huangmei County People's Hospital from June 2022 to June 2024 were selected as the research subjects,they were divided into a control group and an observation group according to the random number table method,with 60 cases in each group.After routine treatment for both groups of children,the control group was treated with AZM,and the observation group was treated with fiberoptic bronchoscopy-alveolar lavage in combination with the treatment of the control group,both groups of children were continuously treated for 12 days.The clinical efficacy,inflammatory indicators,lung function,time for symptom improvement,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 76.67%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6,interferon-γ,and tumor necrosis factor-αin the observation group were lower than those in the control group,the forced expiratory volume in one second,forced vital capacity were greater than those in the control group,and the peak expiratory flow rate was faster than that in the control group,and the differences between the groups were statistically significant(P<0.05).The improvement time of symptoms such as fever,cough,and pulmonary moist rales in the observation group were shorter than those in the control group,and the differences between thegroups were statistically significant(P<0.05).When comparing the incidence of adverse reactions between the two groups,there was no statistically significant difference(P>0.05).Conclusion Fiberoptic bronchoscopy-alveolar lavage combined with AZM can reduce the inflammatory response in children with RMPP,accelerate the recovery

关 键 词：难治性支原体肺炎 阿奇霉素 纤维支气管镜肺泡灌洗 临床疗效 

分 类 号：R725.6[医药卫生—儿科]