黄体酮联合地屈孕酮治疗对黄体功能不全先兆流产患者保胎成功率及血清性激素水平的影响  

Effect of Progesterone Combined with Dydrogesterone on the Success Rate of Fetal Preservation and Serum Sex Hormone Levels in Patients with Threatened Abortion Due to Luteal Phase Deficiency

作　　者：孙小萌 曾婷婷 薛青凤 SUN Xiaomeng;ZENG Tingting;XUE Qingfeng(Graduate School of Zhejiang Chinese Medical University,Hangzhou 310000,China;Department of Obstetrics and Gynecology,Wuxing District People's Hospital of Huzhou City,Zhejiang Province(Wuxing District Maternal and Child Health Hospital of Huzhou City),Huzhou 313008,China)

机构地区：[1]浙江中医药大学研究生院,浙江杭州310000 [2]浙江省湖州市吴兴区人民医院(湖州市吴兴区妇幼保健院)妇产科,浙江湖州313008

出　　处：《反射疗法与康复医学》2024年第24期103-106,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨黄体酮联合地屈孕酮治疗对黄体功能不全(LPD)先兆流产患者的影响。方法选取浙江省湖州市吴兴区人民医院2023年1—12月收治的50例LPD先兆流产患者为研究对象,采用随机数字表法将其分为对照组和研究组,每组25例。对照组采用黄体酮注射液治疗,研究组在对照组的基础上联合地屈孕酮治疗,两组均持续治疗2周。对比两组患者的临床症状消失时间、血清性激素水平、保胎成功率及不良反应发生情况。结果研究组的阴道流血、腰部疼痛、腹部疼痛消失时间分别为(4.11±1.04)d、(3.32±1.04)d、(3.16±1.03)d,均短于对照组的(6.72±1.15)d、(5.45±1.47)d、(4.31±1.27)d,组间差异有统计学意义(P<0.05)。治疗后,研究组的人绒毛膜促性腺激素、血清孕酮、雌二醇水平分别为(7893.06±682.94)U/L、(74.71±8.81)μg/L、(257.89±13.09)pmol/L,均高于对照组的(4681.9±590.49)U/L、(60.62±8.12)μg/L、(206.93±12.07)pmol/L,组间差异有统计学意义(P<0.05)。研究组的保胎成功率为96.00%,高于对照组的64.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论黄体酮联合地屈孕酮治疗能够有效缓解LPD先兆流产患者的临床症状,改善其血清性激素水平,提高保胎成功率,且用药安全性较高。Objective To explore the effect of progesterone combined with dydrogesterone in patients with threatened abortion due to luteal phase deficiency(LPD).Methods Fifty patients with threatened abortion due to LPD treated in Wuxing District People's Hospital of Huzhou City,Zhejiang Province from January to December 2023 were selected as the research objects,and were divided into a control group and a research group by random number table method,with 25 cases in each group.The control group was treated with progesterone injection,and the research group was treated with dydrogesterone in combination on the basis of the treatment regimen of the control group,both groups were treated continuously for 2 weeks.The disappearance time of clinical symptoms,the serum sex hormone levels,the success rate of fetal protection and the occurrence of adverse reactions were compared between the two groups.Results The disappearance time of vaginal bleeding,lumbar pain and abdominal pain in the research group were(4.11±1.04)d,(3.32±1.04)d and(3.16±1.03)d,respectively,which were shorter than(6.72±1.15)d,(5.45±1.47)d and(4.31±1.27)d of the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of human chorionic gonadotropin,serum progesterone and estradiol in the research group were(7893.06±682.94)U/L,(74.71±8.81)μg/L and(257.89±13.09)pmol/L,respectively,which were higher than(4681.9±590.49)U/L,(60.62±8.12)μg/L and(206.93±12.07)pmol/L in the control group,and the differences between the groups were statistically significant(P<0.05).The success rate of fetal protection in the research group was 96.00%,which was higher than 64.00%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was compared between the two groups,the difference was not statistically significant(P>0.05).Conclusion Progesterone combined with dydrogesterone can effectively relieve the clinical symptoms of LPD patients with threatened abortio

关 键 词：黄体功能不全先兆流产 黄体酮 地屈孕酮 保胎成功率 血清性激素水平 

分 类 号：R714.21[医药卫生—妇产科学]