卡前列素氨丁三醇联合缩宫素治疗对宫缩乏力性产后出血患者产后出血量及凝血功能的影响  

Effect of Carboprost Tromethamine Combined with Oxytocin on Postpartum Hemorrhage Volume and Coagulation Function in Patients with Postpartum Hemorrhage Due to Uterine Atony

作　　者：吴春艳 WU Chunyan(Department of Obstetrics and Gynecology,Huishui People's Hospital of Guizhou Province,Huishui 550600,China)

机构地区：[1]贵州省惠水县人民医院妇产科,贵州惠水550600

出　　处：《反射疗法与康复医学》2024年第24期164-166,178,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨宫缩乏力性产后出血(PPH)患者采用卡前列素氨丁三醇联合缩宫素治疗的临床疗效。方法选择2021年3月—2023年3月贵州省惠水县人民医院收治的90例宫缩乏力性PPH患者为研究对象,按随机数字表法将其分为对照组和观察组,每组45例。对照组患者给予缩宫素治疗,观察组患者在对照组基础上给予卡前列素氨丁三醇治疗,两组患者均观察至产后24 h。对比两组的产后出血量、凝血功能、不良反应发生情况。结果产后2 h、24 h,观察组产后出血量分别为(289.60±19.93)mL、(309.06±50.13)mL,均少于对照组的(346.46±25.26)mL、(368.65±60.18)mL,组间差异有统计学意义(P<0.05)。两组产后24 h出血量均多于产后2 h,差异有统计学意义(P<0.05)。产后24 h,观察组活化部分凝血活酶时间、凝血酶原时间均短于对照组,纤维蛋白原水平高于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论予以宫缩乏力性PPH患者卡前列素氨丁三醇联合缩宫素进行治疗,能够获得显著的止血效果,有利于改善凝血功能,且应用安全性较好。Objective To explore the clinical efficacy of carboprost tromethamine combined with oxytocin in patients with postpartum hemorrhage(PPH)due to uterine atony.Methods Ninety patients with PPH due to uterine atony admitted to Huishui People's Hospital of Guizhou Province from March 2021 to March 2023 were selected as the research subjects.They were divided into a control group and an observation group according to the random number table method,with 45 patients in each group.Patients in the control group were treated with oxytocin,while patients in the observation group were treated with carboprost tromethamine on the basis of the control group,both groups of patients were observed until 24 hours after childbirth.The postpartum blood loss,coagulation function,and occurrence of adverse reactions were compared between the two groups.Results At 2 hours and 24 hours postpartum,the postpartum blood loss volumes in the observation group,which were(289.60±19.93)mL and(309.06±50.13)mL,respectively,which were less than(346.46±25.26)mL and(368.65±60.18)mL of the control group,and the differences between the two groups were statistically significant(P<0.05).The blood loss within 24 hours after delivery in both groups were more than those within 2 hours after delivery,and the differences were statistically significant(P<0.05).At 24 hours postpartum,both the activated partial thromboplastin time and the prothrombin time in the observation group were shorter than those in the control group,while the fibrinogen level was higher than that in the control group,and the differences between the two groups were statistically significant(P<0.05).When comparing the incidence of adverse reactions between the two groups,there was no statistically significant difference(P>0.05).Conclusion Treating patients with PPH due to uterine atony with carboprost tromethamine combined with oxytocin can achieve significant hemostatic effects,is beneficial for improving coagulation function,and has good application safety.

关 键 词：宫缩乏力性产后出血 卡前列素氨丁三醇 缩宫素 凝血功能 不良反应 

分 类 号：R714.46[医药卫生—妇产科学]