经颅超声检查黑质强回声在帕金森病早期诊断中的临床应用研究  

Clinical Application of Transcranial Ultrasound Examination with Substantia Nigra Hyperechogenicities for Early Diagnosis of Parkinson's Disease

作　　者：郭永鹤 殷振江[1] 张二轲[1] 赵忻[1] Guo Yonghe;Yin Zhenjiang;Zhang Erke;Zhao Xin(Department of Ultrasound Medicine,Karamay Central Hospital of Xinjiang,Karamay,Xinjiang 834000,China)

机构地区：[1]新疆克拉玛依市中心医院超声医学科,新疆克拉玛依市834000

出　　处：《中国超声医学杂志》2025年第2期121-124,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的本研究旨在对比早期帕金森病患者和健康对照组的黑质强回声特征,以探索黑质强回声在帕金森病早期诊断中的应用价值。方法选取符合国际帕金森及运动障碍学会(MDS)帕金森病诊断标准、年龄在48~80岁的帕金森病患者为观察组A组;同期健康体检者为对照组B组。两组均行经颅超声检查,测定黑质强回声面积、中脑面积、黑质强回声面积/中脑面积(S/M),分析帕金森病患者强回声的变化与年龄、病程及病情严重程度的关系;绘制受试者工作特征(ROC)曲线,分析经颅超声检查黑质强回声在早期帕金森病中的诊断价值及效能,为帕金森病诊疗提供参考依据。结果研究组S/M、黑质强回声面积均较对照组高,差异有统计学意义(P<0.05);研究组S/M的ROC曲线下面积为0.901,灵敏度为86.00%,特异度为82.00%;黑质强回声面积的ROC曲线下面积为0.888,灵敏度为86.00%,特异度为78.00%。结论经颅超声检查对早期帕金森病有较高诊断价值,可以用于帕金森病的早期筛查。Objective This study aims to compare the characteristics of substantia nigra hyperechogenicities between early Parkinson's disease patients and healthy controls,in order to explore the application value of substantia nigra hyperechogenicities in the early diagnosis of Parkinson's disease.Methods Patients in who met the diagnostic criteria of International Parkinson's and Movement Disorders Society(MDS)for Parkinson's disease,aged between 48 and 80,and with Parkinson's disease were selected as observation group A;The health check-up participants during the same period were the control group B.Both groups underwent transcranial ultrasound examination to measure the substantia nigra hyperechogenic area,midbrain,and the substantia nigra hyperechogenic area/midbrain area(S/M).The relationship between changes in the substantia nigra hyperechogenic area and age,disease course,and severity of Parkinson's disease patients was analyzed;drew ROC curve and analyzed the diagnostic value and efficacy of transcranial sonography of hyperechogenicities in the substantia nigra in the early diagnosis of Parkinson's disease,providing reference for the diagnosis and treatment of Parkinson's disease.Results The results showed that the S/M and substantia nigra hyperechoic area in the observation group A were higher than those in the control group B,and the difference was statistically significant(P<0.05);The area under the ROC curve of the S/M study group is 0.901,with a sensitivity of 86.00% and a specificity of 82.00%;The area under the ROC curve of the hyperechogenic area of the substantia nigra is 0888,with a sensitivity of 86.00% and a specificity of 78.00%.Conclusions Transcranial sonography has high diagnostic value for early Parkinson's disease and can be used for early screening of Parkinson's disease.

关 键 词：帕金森病 经颅超声检查 黑质强回声 早期筛查 

分 类 号：R445.1[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]