极早产儿肠道微生物群与神经发育连续性的关系  

The relationship between gut microbiota and neurodevelopmental continuity in very preterm infants

作　　者：张文超 戴立英 Zhang Wenchao;Dai Liying(Department of Neonatology,Anhui Children's Hospital,Anhui Medical University,Fifth Clinical Medical College of Anhui Medical University,Hefei 230000,China)

机构地区：[1]安徽医科大学附属省儿童医院、安徽医科大学第五临床医学院新生儿科,合肥230000

出　　处：《国际儿科学杂志》2025年第1期43-48,共6页International Journal of Pediatrics

基　　金：安徽省财政厅、安徽省卫生健康委员会中央医疗服务与保障能力提升项目(Z155080000004)。

摘　　要：极早产儿(very preterm infant,VPI)是肠道微生物群失调和神经系统发育障碍的高危群体。在生命早期肠道微生物群与神经发育之间存在密切联系,尤其对于VPI,这一联系引起了越来越多的关注。目前对VPI体内微生物-肠-脑轴(microbiota-gut-brain axis,MGBA)的机制缺乏深入了解。通过研究损伤性疾病、感染性疾病及不同肠道菌群发现,生命早期肠道微生物群异常对宿主长期神经发育具有重要影响。该文综述VPI早期发育过程中肠道微生物群与神经系统行为之间的关联,为改善VPI神经发育与生长提供更多参考。Very preterm infant(VPI)is a high-risk group for gut microbiota dysbiosis and neurodevelopmental disorders.There is a strong link between the gut microbiota and neurodevelopment early in life,especially for VPI,and this link has attracted increasing attention.There is a lack of insight into the mechanisms underlying the microbiota-gut-brain axis(MGBA)in VPI.By studying traumatic diseases,infectious diseases,and different gut flora,it is found that early-life intestinal microbiota abnormalities have an important impact on the host's long-term neurological development.This review focuses on the association between gut microbiota and neurological behavior during early development in VPI,and provide reference for improving neurological development and growth in VPI.

关 键 词：极早产儿 肠道微生物群 神经系统发育 微生物群-肠道-大脑轴 

分 类 号：R722.6[医药卫生—儿科]