BaP暴露对女性生殖系统的影响及致病机理的研究进展  

Progress on effects of BaP exposure on female reproductive system and pathogenic mechanisms

作　　者：高倩倩 冯晓玲[2] GAO Qianqian;FENG Xiaoling(Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150000,China;The First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150036,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150000 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150036

出　　处：《环境与职业医学》2024年第12期1432-1437,共6页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金项目(82174421);黑龙江省自然科学基金项目(ZD2021H006)。

摘　　要：苯并[a]芘(BaP)是多环芳烃中含量最高的环境污染物,广泛分布于空气、水、土壤、烧烤及油炸食品中。生活中人类不可避免的接触BaP。研究表明BaP具有生殖毒性,通过影响卵巢激素分泌,干扰卵巢线粒体功能(影响卵母细胞成熟),影响胚胎发育(干扰滋养层细胞迁移、侵袭、增殖、凋亡),影响蜕膜化进程,参与女性生殖系统相关疾病。本文将基于近年来国内外相关研究,对BaP暴露如何影响女性生殖功能及其与流产、生殖系统肿瘤中的研究进展进行总结,以期为未来研究提供依据与新方向。Benzo[a]pyrene(BaP)is the most abundant environmental pollutant among polycyclic aromatic hydrocarbons(PAHs),and is widely distributed in air,water,soil,barbecue,and fried foods.Human beings are inevitably exposed to BaP.Studies have shown that BaP is reproductively toxic and is involved in diseases related to the female reproductive system by affecting the secretion of ovarian hormones,interfering with the function of ovarian mitochondria(affecting oocyte maturation),affecting embryo development(interfering with the migration of trophoblast cells,invasion,proliferation,apoptosis)and the process of metaplasia.This article summarized the research progress on the associations between BaP exposure and female reproductive function,miscarriage,and reproductive system tumors based on relevant studies at home and abroad in recent years,with a view to providing a basis and new direction for future research.

关 键 词：苯并[A]芘 女性生殖 滋养细胞 蜕膜化 流产 

分 类 号：R12[医药卫生—环境卫生学]