全氟及多氟烷基化合物母婴暴露水平及对甲状腺功能影响的作用机制研究进展  

Review on per-and polyfluoroalkyl substances exposure,thyroid function and mechanisms of action in mothers and infants

作　　者：龚乐敏 卢忠武[2] 周钰涵 GONG Lemin;LU Zhongwu;ZHOU Yuhan(School of Exercise and Health,Shanghai University of Sport,Shanghai 200438,China;Fudan University Shanghai Cancer Center,Shanghai 200032,China)

机构地区：[1]上海体育大学运动健康学院,上海200438 [2]复旦大学附属肿瘤医院,上海200032

出　　处：《环境与职业医学》2024年第12期1438-1445,共8页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金项目(82304103);2023年上海高校青年教师培养资助计划项目(A2-0202-24-0004-020)。

摘　　要：全氟及多氟烷基化合物(PFAS)因其疏水疏油的特性,被广泛应用于日常生活中,并在多种环境介质中检出。PFAS可通过水、食物、空气等途径进入人体,并在人体内累积。流行病学和毒理学证据表明,PFAS具有内分泌干扰性,可能会通过影响甲状腺激素稳态,导致甲状腺功能障碍,进而影响人体的正常生理功能,如婴幼儿的体格生长以及神经发育。孕期及生命早期为特殊的生理阶段,该阶段特殊的饮食与生活习惯使得母婴群体更容易接触并受到PFAS的影响。基于以上研究背景,本文对母婴PFAS暴露水平及对母婴甲状腺功能进行综述,并探讨PFAS影响甲状腺可能的机制,有助于为PFAS环境标准及安全限值的制定提供科学依据。Due to the outstanding hydrophobic and oleophobic properties,per-and polyfluoroalkyl substances(PFAS)are widely used in daily life and frequently detected in the environment.PFAS can enter the human body through water,food,and air exposure and accumulate in the human body.Epidemiological and toxicological evidence suggested that PFAS have endocrine-disrupting properties and may cause thyroid dysfunction by altering the hormonal homeostasis of the thyroid.This in turn affects the body's normal physiological functions,such as the physical growth and neurodevelopment in infants.Pregnancy and early life are special physiological stages,and the special dietary and lifestyle habits of this period make mothers and infants more likely to be exposed to PFAS and more susceptible to PFAS.Therefore,the exposure levels of PFAS and their effects on the thyroid function of mothers and infants were summarized in this review.Possible mechanisms of action by which PFAS may affect thyroid function were also summarized,aiming to provide a theoretical basis for the development of environmental standards and safety limits for PFAS.

关 键 词：全氟及多氟烷基化合物 甲状腺 机制 母婴 

分 类 号：R12[医药卫生—环境卫生学]