中医情志疗法联合N-乙酰半胱氨酸对老年慢性阻塞性肺疾病急性加重期患者炎性因子及肺功能的影响  

Effects of Traditional Chinese Medicine Emotional Therapy Combined with N-acetylcysteine on Inflammatory Factors and Pulmonary Function in Elderly Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：刘芮芮 何智慧 张浩跃 陈艳丽 贾闻馨 郑亚男 刘佳 孙丽新 LIU Ruirui;HE Zhihui;ZHANG Haoyue;CHEN Yanli;JIA Wenxin;ZHENG Yanan;LIU Jia;SUN Lixin(Department of Geriatrics,the Health Care Hospital of Chengde City,Chengde,Hebei 067000,China;Department of Pharmacy,the Health Care Hospital of Chengde City,Chengde,Hebei 067000,China;Department of Hemodialysis Room,the Health Care Hospital of Chengde City,Chengde,Hebei 067000,China;Department of Infectious Disease,the Health Care Hospital of Chengde City,Chengde,Hebei 067000,China;Department of Geriatrics,People's Hospital of Shuangluan District,Chengde,Hebei 067000,China)

机构地区：[1]承德市康养医院老年病科,河北承德067000 [2]承德市康养医院药剂科,河北承德067000 [3]承德市康养医院血透室,河北承德067000 [4]承德市康养医院感染科,河北承德067000 [5]承德市双滦区人民医院老年病科,河北承德067000

出　　处：《临床误诊误治》2025年第5期89-93,共5页Clinical Misdiagnosis & Mistherapy

基　　金：2023年承德市科技计划自筹经费项目(202301A009)。

摘　　要：目的探讨中医情志疗法联合N-乙酰半胱氨酸对老年慢性阻塞性肺疾病急性加重期患者炎性因子及肺功能的影响。方法选取2023年4月至2024年4月收治的80例老年慢性阻塞性肺疾病急性加重期患者,采用随机数字表法均分为2组,2组均予常规治疗,对照组予N-乙酰半胱氨酸干预,观察组予中医情志疗法联合N-乙酰半胱氨酸干预,连续干预7 d。比较2组干预前后炎性因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)与肿瘤坏死因子-α(TNF-α)],肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、6 min步行最长距离(6MWD)],负面情绪评分,生活质量以及不良反应情况。结果与对照组比较,观察组干预后IL-6、IL-8、TNF-α水平及焦虑自评量表、抑郁自评量表评分更低,FVC、FEV1、6MWD及生活质量各维度评分更高(P<0.05,P<0.01)。观察组不良反应总发生率为2.50%(1/40)低于对照组的12.50%(5/40),差异有统计学意义(P<0.05)。结论中医情志疗法联合N-乙酰半胱氨酸干预应用于老年慢性阻塞性肺疾病急性加重期患者,能够促使炎性因子水平降低,改善肺功能,减轻负面情绪,提高生活质量,减少不良反应的发生。Objective To investigate the effects of traditional Chinese medicine(TCM)emotional therapy combined with N-acetylcysteine on inflammatory factors and pulmonary function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Methods From April 2023 to April 2024,80 elderly patients with AECOPD were selected and divided into two groups by random number table method.Both groups were given conventioanl treatment.The control group was treated with N-acetylcysteine intervention,and the observation group was treated with TCM emotional therapy combined with N-acetylcysteine intervention for 7 consecutive days.Inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)],pulmonary function indicators[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),maximum walking distance in 6 minutes(6MWD)],negative emotion scores,and the corresponding factors as well as quality of life and adverse reactions were compared before and after intervention in the two groups.Results Compared with the control group,the levels of IL-6,IL-8,TNF-α,self-rating anxiety scale scores and self-rating depression scale scores were lower in the observation group after intervention,and the scores of FVC,FEV1,6MWD and quality of life were higher(P<0.05,P<0.01).The total incidence of adverse reactions in the observation group was 2.50%(1/40),which was lower than that in the control group(12.50%,5/40),showing significant differences(P<0.05).Conclusion TCM emotional therapy combined with N-acetylcysteine intervention in elderly patients with AECOPD can reduce the level of inflammatory factors,improve pulmonary function,alleviate negative emotions,improve quality of life,and reduce the occurrence of adverse reactions.

关 键 词：肺疾病 慢性 阻塞性 老年人 急性加重期 中医情志疗法 N-乙酰半胱氨酸 白细胞介素-6 用力肺活量 生活质量 

分 类 号：R563.9[医药卫生—呼吸系统]