基于数据挖掘分析中医药治疗小儿哮喘的组方用药规律  

Analysis of the Prescription and Medication Rules of Traditional Chinese Medicine in the Treatment of Pediatric Asthma Based on Data Mining

作　　者：陈欣 罗卫华[1] 武伟 陈雪[1] 翟华强[2] CHEN Xin;LUO Weihua;WU Wei;CHEN Xue;ZHAI Huaqiang(Department of Pharmacy,Beijing Hepingli Hospital,Beijing 100013,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京市和平里医院药剂科,北京100013 [2]北京中医药大学中药学院,北京102488

出　　处：《中国医药导刊》2024年第12期1221-1226,共6页Chinese Journal of Medicinal Guide

基　　金：国家卫生健康委员会妇幼保健司基金资助项目(BUCM-2021-KJ-ZYA013)。

摘　　要：目的:基于数据挖掘分析中医药治疗小儿哮喘的组方用药规律。方法:检索中国知网、万方、维普等数据库中2021年6月至2024年8月发表的中医药治疗小儿哮喘相关文献,分析文献中药物使用频次、功效、性味归经、药物配伍,进行聚类分析及复杂网络分析。结果:共涉及到168首方剂共190味中药和1828次用药频次。用药频次≥10次的共有43味中药,用药频次≥20次的共有28味中药;用药频次排在前10位的中药依次为甘草、麻黄、杏仁、半夏、五味子、茯苓、白术、黄芪、苏子、地龙、陈皮;用药频次排名前5位的中药类型分别为化痰止咳药、解表药、补气药、清热药、补虚药。药性方面以温药和平药为主,五味方面以甘、辛和苦药为主,归经方面多归肺、脾、胃三经。Apriori分析显示,杏仁、麻黄、甘草、半夏、五味子、茯苓、白术等药物之间的配伍最为频繁。系统聚类法得到6种药物分类。复杂网络分析显示甘草、杏仁、半夏等共现频次最高,其次为茯苓、五味子、陈皮、白术、黄芪等药物。结论:近年来中医药治疗小儿哮喘的综合性治疗策略是在缓解症状的同时注重调理和增强体质。Objective:To analyze the prescription and medication rules of traditional Chinese medicine in the treatment of pediatric asthma based on data mining.Methods:Literature related to the treatment of pediatric asthma by traditional Chinese medicine published between June 2021 and August 2024 in CNKI,Wanfang,and VIP were searched.Data analysis focused on drug usage frequency,medicinal properties,flavor and meridian tropism,drug compatibility,cluster analysis,and complex network analysis.Results:A total of 168 prescriptions,190 traditional Chinese medicines(TCMs),and 1828 times of medication frequency were included.Among these,43 TCMs had a frequency of use≥10 times,and 28 TCMs had a frequency of use≥20 times.The top 10 TCMs in the frequency of use were Licorice,Ephedra,Almond,Pinellia ternata,Schisandra chinensis,Poria cocos,Atractylodes macrocephala,Astragalus membranaceus,Perillaseed,Pberetima,and Aged citrus peel.The top 5 types of TCM in the frequency of use were phlegm-resolving medicine,exterior-releasing medicine,qi-tonifying medicine,heat-clearing medicine and deficiency-tonifying medicine.In terms of medicinal properties,warm and neutral herbs predominated.The most common flavors were sweet,pungent,and bitter,while the main meridian tropism were lung,spleen,and stomach meridians.Apriori analysis showed that combinations of Almond,Ephedra,Licorice,Pinellia ternata,Schisandra chinensis,Poria cocos,and Atractylodes macrocephala occurred most frequently.Cluster analysis identified six major drug classification.Complex network analysis showed that Licorice,Almond,and Pinellia ternata had the highest co-occurrence frequencies,followed by Poria cocos,Schisandra chinensis,Aged citrus peel,Atractylodes macrocephala,and Astragalus membranaceus.Conclusion:In recent years,the comprehensive treatment strategy of Chinese medicine for pediatric asthma focuses on physical regulation and enhancement of the body's overall constitution while relieving symptoms.

关 键 词：小儿哮喘 中医药 数据挖掘 组方规律 

分 类 号：R256.12[医药卫生—中医内科学]