外用青黛制剂治疗寻常型银屑病的系统评价和Meta分析  

Topical Indigo Naturalis Preparations for the Treatment of Psoriasis Vulgaris:A Systematic Review and Meta-Analysis

作　　者：方宜梅 万盈盈 黄瑞音 胡博 张丰川[1] 李元文[1] 蔡玲玲[1] FANG Yimei;WAN Yingying;HUANG Ruiyin;HU Bo;ZHANG Fengchuan;LI Yuanwen;CAI Lingling(Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《中国医药导刊》2024年第12期1246-1256,共11页Chinese Journal of Medicinal Guide

基　　金：北京市自然科学基金(7232295);北京市自然科学基金(7192116);北京中医药大学青年教师项目(2018-JYBZZ-JS142);北京市中医药管理局首批“十四五”中医药重点专科(BJZKBC0015);中华中医药学会基于国省标中药配方颗粒临床研究专项(ZB-CACM-2024010)。

摘　　要：目的:系统评价《中国银屑病诊疗指南(2023版)》中外用青黛制剂治疗寻常型银屑病的有效性和安全性。方法:检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Cochrane Library及Embase数据库,收集建库至2024年12月7日外用青黛制剂治疗寻常型银屑病的随机对照研究。采用Cochrane风险评价工具评估研究质量,使用RevMan 5.4.1软件进行统计分析。结果:共纳入17项研究,涉及1134例寻常型银屑病患者。Meta分析结果显示:与安慰剂、阳性药相比,外用青黛制剂治疗寻常型银屑病临床总有效率更优;在降低银屑病面积和严重程度指数(PASI)评分方面,外用青黛制剂优于安慰剂,与阳性药效果相当。以上均提示外用青黛制剂治疗寻常型银屑病的疗效较好。安全性方面,青黛制剂不良反应发生率高于安慰剂但低于阳性药。结论:现有证据表明外用青黛制剂治疗寻常型银屑病有效且相对安全,但受文献质量和发表偏倚影响,需更多高质量研究验证。Objective:To systematically evaluate the efficacy and safety of topical Indigo Naturalis preparations in the treatment of psoriasis vulgaris based on the Chinese Guidelines for the Diagnosis and Treatment of Psoriasis(2023 Edition).Methods:Databases including CNKI,Wanfang Data,VIP,SinoMed,PubMed,Cochrane Library,and Embase were searched for randomized controlled trials(RCTs)on the use of topical Indigo Naturalis preparations for psoriasis vulgaris from inception to December 7,2024.The Cochrane risk assessment tool was employed to assess the quality of the studies,and statistical analysis was conducted using RevMan 5.4.1 software.Results:A total of 17 studies involving 1134 patients with psoriasis vulgaris were included.Meta-analysis results indicated that compared with placebo and positive controlled drug,topical Indigo Naturalis preparations exhibited better overall clinical effectiveness in the treatment of psoriasis vulgaris.In terms of reducing the Psoriasis Area and Severity Index(PASI)scores,topical Indigo Naturalis preparations were superior to placebo and comparable to positive controlled drug.These findings collectively suggest that topical Indigo Naturalis preparations are efficacious in the treatment of psoriasis vulgaris.Regarding safety,the adverse reaction rate associated with Indigo Naturalis preparations was higher than that of placebo but lower than that of positive controlled drug.Conclusion:Existing evidence suggests that topical Indigo Naturalis preparations are effective and relatively safe for the treatment of psoriasis vulgaris.However,due to limitations in literature quality and publication bias,more high-quality studies are needed for verification.

关 键 词：寻常型银屑病 青黛制剂 中药 外用 随机对照 系统评价 META分析 

分 类 号：R758[医药卫生—皮肤病学与性病学]